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ProteomicsAn effective plasma membrane proteomics approach for small tissue samples
Advancing the quest for new drug targets demands the development of innovative plasma membrane proteome research strategies applicable to small, functionally defined tissue samples. Biotinylation of acute tissue slices and streptavidin pull-down followed by shotgun proteomics allowed the selective e...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-22 | PXD002227 | Pride
Orbitrap velos Affinity-purification Mice Acute slice biotinylation assay Membrane proteomics Shotgun proteomics 
MetabolomicsFour layer multi-omics reveals molecular responses to aneuploidy in Leishmania

Aneuploidy causes system-wide disruptions in the stochiometric balances of transcripts, proteins, and metabolites, often resulting in detrimental effects for the organism. The protozoan parasite Leishmania has an unusually high tolerance for aneuploidy, but the molecular and functional consequenc...

2022-09-19 | MTBLS1612 | MetaboLights
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