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UnknownPolymeric Nanovehicle of α-Tocopheryl Succinate Based on a Methacrylic Derivative of Hydroxychloroquine and Its Cytotoxic Effect on Breast Cancer Cells.
This study focuses on the preparation of poly(HCQM-co-VP) copolymeric nanoparticles (NPs) to enhance the aqueous solubility and bioavailability of the hydrophobic and antitumor molecules HCQ (hydroxychloroquine) and α-TOS (α-tocopheryl succinate). HCQ is covalently incorporated into the polym...
S-EPMC12526677 | biostudies-literature
UnknownPhase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma.
Purpose DNX-2401 (Delta-24-RGD; tasadenoturev) is a tumor-selective, replication-competent oncolytic adenovirus. Preclinical studies demonstrated antiglioma efficacy, but the effects and mechanisms of action have not been evaluated in patients. Methods A phase I, dose-escalation, biologic-end-point ...
S-EPMC6075856 | biostudies-literature
UnknownCardiovascular Outcomes in Hospitalized Patients with COVID-19: Does Age Really Matter?

Background

An advanced age elevates risk for COVID-19-related cardiovascular complications and mortality. This study analyzes cardiovascular comorbidities and outcomes in hospitalized COVID-19 patients across age groups to assess its impact.

Methods

The CARDIO COVID 19-20 registry is ...
S-EPMC11856037 | biostudies-literature
UnknownA case-control study of post-operative endophthalmitis diagnosed at a Spanish hospital over a 13-year-period.
A retrospective case-control study of patients who had undergone cataract extraction at a Spanish hospital over a 13-year period was conducted to identify the risk factors for developing post-operative endophthalmitis (POE). During the study period, the type of antibiotic prophylaxis was changed fro...
S-EPMC9206787 | biostudies-literature
UnknownCalcium/calmodulin kinase1 and its relation to thermotolerance and HSP90 in Sporothrix schenckii: an RNAi and yeast two-hybrid study.

Background

Sporothrix schenckii is a pathogenic dimorphic fungus of worldwide distribution. It grows in the saprophytic form with hyaline, regularly septated hyphae and pyriform conidia at 25°C and as the yeast or parasitic form at 35°C. Previously, we characterized a calcium/calmodulin kina...
S-EPMC3146815 | biostudies-literature
UnknownB cells as modulators of HPV+ oropharyngeal cancer in a preclinical model.
Among the different immune cells present within tumors, B cells also infiltrate human papillomavirus-positive (HPV+) oropharyngeal tumors. However, the role of B cells during programmed death-1 (PD-1) blockade in HPV+ oropharyngeal cancer needs to be better defined. By using the preclinical mouse mo...
S-EPMC10076859 | biostudies-literature
UnknownGenome Sequence of the Pathogenic Fungus Sporothrix schenckii (ATCC 58251).
Sporothrix schenckii is a pathogenic dimorphic fungus that grows as a yeast and as mycelia. This species is the causative agent of sporotrichosis, typically a skin infection. We report the genome sequence of S. schenckii, which will facilitate the study of this fungus and of the Sporothrix schenckii...
S-EPMC4031338 | biostudies-literature
UnknownNovel Bioactive and Antibacterial Acrylic Bone Cement Nanocomposites Modified with Graphene Oxide and Chitosan.
Acrylic bone cements (ABCs) have played a key role in orthopedic surgery mainly in arthroplasties, but their use is increasingly extending to other applications, such as remodeling of cancerous bones, cranioplasties, and vertebroplasties. However, these materials present some limitations related to ...
S-EPMC6627441 | biostudies-literature
UnknownComparative mRNA profile analysis from NAc of adolescent male mice after binge-like alcohol exposure eliciting deficits in context fear extinction learning.

Introduction

Stressor-related disorders frequently co-occur with alcohol use disorder (AUD). This necessitates an understanding of the physiological and genetic factors contributing to this relationship. Binge drinking is the most common method of alcohol consumption among adolescent males a...
S-EPMC12193044 | biostudies-literature
UnknownClinicopathological correlates in the frontotemporal lobar degeneration-motor neuron disease spectrum.
Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease (MND) that shares a common clinical, genetic and pathologic spectrum with frontotemporal dementia (FTD). It is highly heterogeneous in its presentation and features. Up to 50% of patients with MND develop cognitive-behavioural...
S-EPMC11224598 | biostudies-literature
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