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UnknownInsecticide Resistance and Fitness: The Case of Four Aedes aegypti Populations from Different Brazilian Regions.

Background

Chemical control is still a major strategy to constrain vector density and mitigate pathogen transmission. However, insecticide overuse poses a high selective pressure, favouring the spread of resistance alleles in natural populations. In an insecticide-free environment, a fitness...
S-EPMC6198578 | biostudies-literature
GenomicsThe chromatin remodeler ATRX binds to atypical chromatin domains at the 3’ exons of ZNF genes to preserve H3K9me3 enrichment
Here, we report that ATRX co-localizes with the H3K9-methyl transferase SETDB1 (also known as ESET), the co-repressor TRIM28 (also known as KAP1), and the transcription factor ZNF274 at 3’ exons of Zinc Finger Genes (ZNFs) containing an atypical H3K9me3/H3K36me3 chromatin signature. Disruption of ...
ORGANISM(S): Homo sapiens 
2016-04-05 | E-GEOD-70920 | biostudies-arrayexpress
TranscriptomicsHistone variant H2A.Z.2 mediates proliferation and drug sensitivity of malignant melanoma (expression)
Here we report a novel role for H2A.Z.2 (H2AFV) as a mediator of cell proliferation and sensitivity to targeted therapies in malignant melanoma. While both H2A.Z.1 and H2A.Z.2 are highly expressed in metastatic melanoma and correlate with decreased patient survival, only H2A.Z.2 deficiency results i...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-59026 | biostudies-arrayexpress
UnknownMacrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma.

Objective

The lysyl oxidase-like protein 2 (LOXL2) contributes to tumour progression and metastasis in different tumour entities, but its role in pancreatic ductal adenocarcinoma (PDAC) has not been evaluated in immunocompetent in vivo PDAC models.

Design

Towards this end, we used PDA...
S-EPMC9872246 | biostudies-literature
TranscriptomicsAffymetrix SNP array data for short-segment Hirschsprung trios
Finding gene associations in rare diseases is frequently hampered by the reduced numbers of patients accessible. Conventional gene-based association tests rely on the availability of large cohorts, which constitutes a serious limitation for its application in this scenario. To overcome this problem ...
ORGANISM(S): Homo sapiens 
2012-03-18 | E-GEOD-33732 | biostudies-arrayexpress
TranscriptomicsHistone variant H2A.Z.2 mediates proliferation and drug sensitivity of malignant melanoma [RNA-seq]
Here we report a novel role for H2A.Z.2 (H2AFV) as a mediator of cell proliferation and sensitivity to targeted therapies in malignant melanoma. While both H2A.Z.1 and H2A.Z.2 are highly expressed in metastatic melanoma and correlate with decreased patient survival, only H2A.Z.2 deficiency results i...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-68221 | biostudies-arrayexpress
GenomicsHistone variant H2A.Z.2 mediates proliferation and drug sensitivity of malignant melanoma [native ChIP-seq]
Here we report a novel role for H2A.Z.2 (H2AFV) as a mediator of cell proliferation and sensitivity to targeted therapies in malignant melanoma. While both H2A.Z.1 and H2A.Z.2 are highly expressed in metastatic melanoma and correlate with decreased patient survival, only H2A.Z.2 deficiency results i...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-68222 | biostudies-arrayexpress
GenomicsHistone variant H2A.Z.2 mediates proliferation and drug sensitivity of malignant melanoma [ChIP-seq]
Here we report a novel role for H2A.Z.2 (H2AFV) as a mediator of cell proliferation and sensitivity to targeted therapies in malignant melanoma. While both H2A.Z.1 and H2A.Z.2 are highly expressed in metastatic melanoma and correlate with decreased patient survival, only H2A.Z.2 deficiency results i...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-68223 | biostudies-arrayexpress
UnknownAbdominal infections in the intensive care unit: characteristics, treatment and determinants of outcome.

Background

Abdominal infections are frequent causes of sepsis and septic shock in the intensive care unit (ICU) and are associated with adverse outcomes. We analyzed the characteristics, treatments and outcome of ICU patients with abdominal infections using data extracted from a one-day poin...
S-EPMC4122779 | biostudies-literature
UnknownPrognostic Factors of Late-onset Hearing Loss in Infants With Congenital Cytomegalovirus and Normal Audiologic Assessment at Birth.

Background

Children with congenital cytomegalovirus (cCMV) can develop late-onset sensorineural hearing loss (LO-SNHL). In this study, we aim to assess the characteristics and predictors of LO-SNHL in infants with cCMV having normal hearing at the first neonatal assessment.

Methods

A ...
S-EPMC12688458 | biostudies-literature
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