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TranscriptomicsIntegrating high-dimensional transcriptomics and image analysis tools into early safety screening (I)
In this paper we demonstrated the potential to flag toxicity issues by utilizing data from exploratory experiments which are typically generated for target evaluation purposes during early drug discovery During drug discovery and development, the early identification of adverse effects is expected t...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-70611 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of nodose or dorsal root ganglion visceral sensory neurons from mice infected with N. brasiliensis and/or subjected to environmental stress to determine molecular signatures for post-infective visceral chemosensitivity associated with irritable bowel syndrome
Background & Aims: Visceral hypersensitivity, a hallmark of irritable bowel syndrome, is generally considered to be mechanosensitive in nature and mediated via spinal afferents. Both stress and inflammation are implicated in visceral hypersensitivity, but the underlying molecular mechanisms of visce...
ORGANISM(S): Mus musculus 
2008-01-31 | E-JJRD-1 | biostudies-arrayexpress
TranscriptomicsIntegrating high-dimensional transcriptomics and image analysis tools into early safety screening (II)
In this paper we demonstrated the potential to flag toxicity issues by utilizing data from exploratory experiments which are typically generated for target evaluation purposes during early drug discovery During drug discovery and development, the early identification of adverse effects is expected t...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-70613 | biostudies-arrayexpress
TranscriptomicsIntegrating high-dimensional transcriptomics and image analysis tools into early safety screening (III)
In this paper we demonstrated the potential to flag toxicity issues by utilizing data from exploratory experiments which are typically generated for target evaluation purposes during early drug discovery During drug discovery and development, the early identification of adverse effects is expected t...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-70614 | biostudies-arrayexpress
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