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TranscriptomicsProtein phosphatase PP1-NIPP1 activates mesenchymal genes in HeLa cells
The deletion of the protein phosphatase-1 (PP1) regulator NIPP1 is embryonic lethal during gastrulation, hinting at a key role of PP1-NIPP1 in lineage specification. Consistent with this notion we show here that a mild, stable overexpression of NIPP1 in HeLa cells caused a massive in...
ORGANISM(S): Homo sapiens 
2015-04-04 | E-GEOD-67558 | biostudies-arrayexpress
TranscriptomicsExpression profiling of HeLa Tet-off cells expressing Flag-tagged version of WT NIPP1 or PP1 binding mutant of NIPP1.
NIPP1, an established interactor of protein phosphatase 1 (PP1), is implicated in PRC2-mediated regulation of gene expression. Here, we explore whether PP1 associated with NIPP1 is involved in NIPP1-mediated regulation of genes. Therefore, we generated Hela Tet-off (HTO) cell lines that stably and i...
ORGANISM(S): Homo sapiens 
2010-07-19 | E-GEOD-19642 | biostudies-arrayexpress
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