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TranscriptomicsCancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells
This SuperSeries is composed of the following subset Series: GSE29870: Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells (expression data) GSE29872: Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells (methyl...
ORGANISM(S): Homo sapiens 
2011-06-16 | E-GEOD-29873 | biostudies-arrayexpress
TranscriptomicsPolycomb CBX7 represses expression of tumor suppressor genes
Polycomb CBX7 was stably expressed in embryonal carcinoma cells in order to identify target genes. The study was specifically geared toward unveiling gene targets that are susceptible to DNA hypermethylation in adult cancer. A number of CBX7 target tumor suppressor genes were thereby identified an...
ORGANISM(S): Homo sapiens 
2009-09-23 | E-GEOD-10541 | biostudies-arrayexpress
TranscriptomicsCancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells (methylation data)
he ability to induce pluripotent stem cells from committed, somatic human cells provides tremendous potential for regenerative medicine. However, there is a defined neoplastic potential inherent to such reprogramming that must be understood and may provide a model for understanding key events in tum...
ORGANISM(S): Homo sapiens 
2011-06-16 | E-GEOD-29872 | biostudies-arrayexpress
TranscriptomicsCancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells (expression data)
The ability to induce pluripotent stem cells from committed, somatic human cells provides tremendous potential for regenerative medicine. However, there is a defined neoplastic potential inherent to such reprogramming that must be understood and may provide a model for understanding key events in tu...
ORGANISM(S): Homo sapiens 
2011-06-16 | E-GEOD-29870 | biostudies-arrayexpress
TranscriptomicsConvergence of Mutation and Epigenetic Alterations Identifies Common Target Genes in Breast and Colon Cancer
The identification and characterization of tumor suppressor genes has enhanced our understanding of the biology of cancer and enabled the development of new diagnostic and therapeutic modalities. Whereas in past decades, a handful of tumor suppressors have been slowly identified using techniques su...
ORGANISM(S): Homo sapiens 
2009-09-23 | E-GEOD-10613 | biostudies-arrayexpress
TranscriptomicsIdentification of pathways involved in lung carcinoid progression using gene expression profiling
Identification of differentially expressed genes between pulmonary carcinoid patients with a favorable and a poor disease outcome
ORGANISM(S): Homo sapiens 
2013-03-26 | E-MEXP-3790 | biostudies-arrayexpress
TranscriptomicsIdentifying functional CpG island methylation markers in clear cell renal cell cancer cell lines
Clear cell renal cell carcinoma (ccRCC) is the most common adult renal cancer. Although the molecular characteristics of ccRCC are currently being studied, the biologically and clinically relevant ccRCC methylome remains to be elucidated. To explore the RCC hypermethylome we employed massive sequenc...
ORGANISM(S): Homo sapiens 
2013-11-22 | E-GEOD-33916 | biostudies-arrayexpress
TranscriptomicsEffects of DAC treatment
Reversal of gene promoter DNA hypermethylation and associated abnormal gene silencing is an attractive approach to cancer therapy. The DNA methylation inhibitor, decitabine (5-aza-2'-deoxycitidine), is proving efficacious for hematological neoplasms especially at lower, less toxic, doses. Experiment...
ORGANISM(S): Homo sapiens 
2012-03-21 | E-GEOD-20945 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CT116 cells and isogenic genetic knockouts rveals identity of the human cancer cell DNA hypermethylome
Altered gene expression is a hallmark of human cancers and arises in part through abnormal epigenetic regulation of gene transcription. The best characterized epigenetic alteration involves tumor suppressor gene inactivation via transcriptional repression associated with aberrant DNA hypermethylatio...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4763 | biostudies-arrayexpress
TranscriptomicsGenome-wide total RNA and MBD-sequencing in HCT116 and DKO cells as a global re-expression model [RNA-Seq]
Genome-wide view of the interplay between methylation and RNA expression in this colorectal cancer model was obtained. RNA-sequencing of HCT116 cell line, the DNMT1 and DNMT3B double knock-out HCT116 cell line (DKO), and 7 additional colorectal cell lines.
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-45332 | biostudies-arrayexpress
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