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TranscriptomicsGene expression analysis of Early immature and Late mature T-ALL cell lines
Early immature T-cell acute lymphoblastic leukemias (T-ALLs) account for about 5-10% of pediatric T-ALLs and are associated with poor prognosis. However, the genetic defects that drive the biology of these tumors remain largely unknown. Analysis of microarray gene expression signatures in adult T-AL...
ORGANISM(S): Homo sapiens 
2013-06-18 | E-GEOD-48046 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling in pediatric AML
MicroRNAs (miRNAs) play a pivotal role in the regulation of hematopoiesis and development of leukemia. Great interest emerged in modulating miRNA expression for therapeutic purposes. In order to identify miRNAs, which specifically suppress leukemic growth of AML with t(8;21), inv(16) or MLL-rearrang...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-52541 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for RUNX1 knockdown in the ALL-SIL cell line.
The T-cell leukemia homeobox 1 (TLX1, HOX11) transcription factor is critically involved in the multistep pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanisms by which t...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-62140 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for ETS1 knockdown in the ALL-SIL cell line.
The T-cell leukemia homeobox 1 (TLX1, HOX11) transcription factor is critically involved in the multistep pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanisms by which t...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-62135 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for JQ1 treatment of the ALL-SIL cell line.
The T-cell leukemia homeobox 1 (TLX1, HOX11) transcription factor is critically involved in the multistep pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanisms by which t...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-62139 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for TLX1 knockdown in the ALL-SIL cell line.
The T-cell leukemia homeobox 1 (TLX1, HOX11) transcription factor is critically involved in the multistep pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanisms by which t...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-62141 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of the GSI treatment of the CUTLL1 cell line
Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of oncogenic and loss-of-function mutations. Amongst this plethora of genetic changes, NOTCH1 activating mutations stand out as the most frequently occurring genetic defect, identified in more than 50% of T...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-61999 | biostudies-arrayexpress
UnknownLong non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia.
Not available
S-EPMC7854679 | biostudies-literature
UnknownSHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival.
Not available
S-EPMC6189109 | biostudies-literature
UnknownCommercial wound dressings for the treatment of exuding wounds: an in-depth physico-chemical comparative study.
Not available
S-EPMC9210940 | biostudies-literature
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