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TranscriptomicsA cell atlas of human thymic development defines T cell repertoire formation
We performed single-cell RNA-sequencing to create a cell census of the human thymus during development, early childhood and adult life. We sampled 15 embryonic and fetal thymi spanning thymic developmental stages between 7 post-conception weeks (PCW) to 17 PCW, and 9 postnatal thymi from paediatric ...
ORGANISM(S): Mus musculus 
2020-02-21 | E-MTAB-8581 | biostudies-arrayexpress
ProteomicsSingle-cell transcriptional profiling identifies a spectrum of unconventional intraepithelial T lineage cells in human cord blood
Conventional CD4 and CD8 single positive T cell lineages constitute the main differentiation pathway in the thymus. In human thymus, a minor TCRαβ differentiation pathway diverges from the early double positive stage, consisting of CD10+ PD-1+ cells. These cells are phenotypically and functionally s...
ORGANISM(S): Homo sapiens (Human) 
2023-02-10 | PXD033392 | Pride
Agonist-selection T cell lineages Shotgun proteomics Q exactive hf Human Intraepithelial t cells Cord blood Label-free Thymus 
UnknownB cell helper T cells and type 1 diabetes.
Not available
S-EPMC7583378 | biostudies-literature
ProteomicsNeoantigen targeted dendritic cell vaccine generates durable T cell responses exhibiting the full spectrum of differentiation states in NSCLC patients
Background. Dendritic cell (DC)-based neoantigen vaccination holds potential as a safe and effective adjuvant therapy for patients with early-stage, resectable NSCLC, a tumor type typically characterized by high mutational loads. DCs have the unique ability to elicit robust antitumoral T-cell respon...
ORGANISM(S): Homo sapiens (Human) 
2024-03-17 | PXD044799 | Pride
Cancer Lung non-small cell carcinoma Vaccine Neoantigen Human 
UnknownThymoSpheres culture: A model to study human polyclonal unconventional T cells.
Not available
S-EPMC11628907 | biostudies-literature
ProteomicsNeoantigen targeted dendritic cell vaccine generates durable T cell responses exhibiting the full spectrum of differentiation states in NSCLC patients
Background. Dendritic cell (DC)-based neoantigen vaccination holds potential as a safe and effective adjuvant therapy for patients with early-stage, resectable NSCLC, a tumor type typically characterized by high mutational loads. DCs have the unique ability to elicit robust antitumoral T-cell respon...
ORGANISM(S): Homo sapiens (Human) 
2024-03-17 | PXD044794 | Pride
Human Cancer Non-small cell lung cancer Vaccine Neoantigen Dendritic cells 
UnknownA genetic IFN/STAT1/FAS axis determines CD4 T stem cell memory levels and apoptosis in healthy controls and Adult T-cell Leukemia patients.
Not available
S-EPMC5927537 | biostudies-literature
UnknownFamily Aggregation of Human T-Lymphotropic Virus 1-Associated Diseases: A Systematic Review.
Not available
S-EPMC5083714 | biostudies-literature
UnknownOncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia.
Not available
S-EPMC5783288 | biostudies-literature
UnknownSingle-cell profiling identifies a novel human polyclonal unconventional T cell lineage.
Not available
S-EPMC10037106 | biostudies-literature
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