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ProteomicsGenetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes
Type 1 and type 2 diabetes (T1D and T2D) share pathophysiological characteristics, yet mechanistic links have remained elusive. T1D results from autoimmune destruction of pancreatic beta cells, while beta cell failure in T2D is delayed and progressive. Here we find a new genetic component of diabete...
ORGANISM(S): Mus musculus (Mouse) 
2016-02-24 | PXD000859 | Pride
B10 mice Inshel Diabetes Nod mice 
ProteomicsThe dynamics of protein-bound methionine oxidation events in Arabidopsis thaliana during oxidative stress
Reactive oxygen species such as hydrogen peroxide can modify proteins via direct oxidation of their sulfur-containing amino acids, cysteine and methionine. Methionine oxidation, studied here, is a reversible posttranslational modification, which is increasingly suggested as a mechanism by which prot...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2015-03-24 | PXD001286 | Pride
Methionine oxidation Catalase mutant Oxidative stress Arabidopsis thaliana 
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