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TranscriptomicsSingle-cell transcriptomics of neonatal mouse anterior pituitary in steady-state conditions and after transgenically inflicted local damage
The mouse pituitary gland undergoes vivid maturation immediately after birth. During this process, the local stem cell compartment shows signs of activation including elevated abundance and expression of stemness pathways when compared to adult pituitary stem cells. In addition, we found that the ne...
ORGANISM(S): Mus musculus 
2022-07-11 | E-MTAB-11337 | biostudies-arrayexpress
TranscriptomicsSingle cell transcriptional profiling of mouse molar and incisor tooth assembloids
Throughout the various stages of tooth development, reciprocal epithelial-mesenchymal interactions are the driving force, for instance crucially involved in the differentiation of mature enamel-forming ameloblasts and dentin-producing odontoblasts. Here we established mouse tooth ‘assembloids’, comp...
ORGANISM(S): Mus musculus 
2023-04-19 | E-MTAB-12544 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptomics of elderly mouse anterior pituitary in steady-state conditions and after transgenically inflicted local damage
The mouse pituitary gland houses a stem cell compartment which is known to suffer from an inflammatory phenotype at middle age (12-15 months), a process commonly referred to as ‘inflammaging’. Here, we investigate the aging pituitary stem cell phenotype by using single-cell RNA-sequencing interrogat...
ORGANISM(S): Mus musculus 
2025-01-06 | E-MTAB-14067 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptional profiling of young-adult and aging (middle-aged) mouse anterior pituitary in steady-state conditions and after transgenically inflicted local damage
Adult pituitary stem cells (SC) are mainly dormant, yet in the case of damage the resident SC compartment shows swift activation. More in particular, following diphtheria toxin (DT)-triggered endocrine cell-ablation injury in the GHCre/iDTR mouse model (expressing the Cre recombinase under control o...
ORGANISM(S): Mus musculus 
2021-06-15 | E-MTAB-10021 | biostudies-arrayexpress
TranscriptomicsHuman pancreatic adenocarcinoma contains a side population resistant to gemcitabine
BACKGROUND: Therapy resistance remains one of the major challenges to improve the prognosis of patients with pancreatic cancer. Chemoresistant cells, which potentially also display cancer stem cell (CSC) characteristics, can be isolated using the side population (SP) technique. Our aim was to search...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-36563 | biostudies-arrayexpress
TranscriptomicsMolecular markers associated with outcome and metastasis in human pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous cancer in which differences in survival rates might be related to a variety in gene expression profiles. Although the molecular biology of PDAC begins to be revealed, genes or pathways that specifically drive tumour progression or metastasis...
ORGANISM(S): Homo sapiens 
2013-01-09 | E-GEOD-42952 | biostudies-arrayexpress
TranscriptomicsThe side population of human pancreatic cancer expresses cancer stem cell-associated genes
Purpose: To explore the side population (SP) in pancreatic ductal adenocarcinoma (PDAC) for its gene expression profile and its association to cancer stem cells (CSC) and to evaluate the value of genes from its gene signature on patient survival. Experimental design: Side and main population (MP) c...
ORGANISM(S): Homo sapiens 
2014-09-26 | E-GEOD-42404 | biostudies-arrayexpress
TranscriptomicsSide population cells in human primary melanoma
Melanoma remains the most lethal skin cancer, mainly because of high resistance to therapy. Side population (SP) cells are found in many types of cancer and are usually enriched in therapy-resistant as well as tumorigenic cells. Here, we identified a Hoechst dye-effluxing SP in a large series of hum...
ORGANISM(S): Homo sapiens 
2014-05-27 | E-GEOD-48838 | biostudies-arrayexpress
TranscriptomicsPituitary tumors contain a (CD31¯/CD45¯ purified) side population with 'tumor stem cell'-associated characteristics [set 2]
Pituitary adenomas cause significant endocrine and mass-related morbidity. Not much is known about mechanisms underlying pituitary tumor pathogenesis. We searched for a side population (SP) in pituitary tumor, representing cells with high efflux capacity and potentially enriching for cancer/tumor st...
ORGANISM(S): Homo sapiens 
2015-08-04 | E-GEOD-62870 | biostudies-arrayexpress
TranscriptomicsPituitary tumors contain a side population with 'tumor stem cell'-associated characteristics [set 1]
Pituitary adenomas cause significant endocrine and mass-related morbidity. Not much is known about mechanisms underlying pituitary tumor pathogenesis.We searched for a side population (SP) in pituitary tumor, representing cells with high efflux capacity and potentially enriching for cancer/tumor ste...
ORGANISM(S): Homo sapiens 
2015-08-04 | E-GEOD-62866 | biostudies-arrayexpress
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