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TranscriptomicsSingle-cell copy number varation detection
Detection of genomic rearrangements from a single cell instead of a population of cells is an emerging research technique with important applications in the study of human fertility, constitutional chromosomal disorders, and tumor progression. Here, we develop a method to improve the detection of si...
ORGANISM(S): Homo sapiens 
2011-08-23 | E-GEOD-27892 | biostudies-arrayexpress
Transcriptomicsarray-CGH on single blastomeres from day-3 human cleavage stage embryos
Seventy blastomeres from fourteen frozen-thawed supernumerary human preimplantation embryos were disassociated and genomic was amplified using Multiple Displacement Amplification. BAC array-CGH was performed on the amplified products. BAC array-CGH on single blastomeres amplified by Multiple Displac...
ORGANISM(S): Homo sapiens 
2012-10-15 | E-GEOD-34290 | biostudies-arrayexpress
TranscriptomicsGenome-wide haplotyping of human single cells
A method to infer genome-wide haplotypes from the analysis of one or two single (human) cells has tremendous applicative value. It would revolutionize not only preimplantation genetic diagnosis of in vitro fertilized human embryos in the clinic, but also animal breeding programs by enabling genome-w...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-17318 | biostudies-arrayexpress
TranscriptomicsIdentification of DNA-replication domains in single S-phase cells: part 3 whole genome amplified single-cell DNA
DNA-replication is a key process in life and can lead to disease when disturbed. Cell-type specific early and late replication domains have been discovered throughout genomes by analysis of DNA from populations of cells. However, cell to cell differences and the association of these differences with...
ORGANISM(S): Homo sapiens 
2013-01-08 | E-GEOD-38760 | biostudies-arrayexpress
TranscriptomicsIdentification of DNA-replication domains in single S-phase cells: part 4 whole genome amplified single-cell DNA
DNA-replication is a key process in life and can lead to disease when disturbed. Cell-type specific early and late replication domains have been discovered throughout genomes by analysis of DNA from populations of cells. However, cell to cell differences and the association of these differences with...
ORGANISM(S): Homo sapiens 
2013-01-08 | E-GEOD-41776 | biostudies-arrayexpress
TranscriptomicsIdentification of DNA-replication domains in single S-phase cells: part 3 multi-cell controls
DNA-replication is a key process in life and can lead to disease when disturbed. Cell-type specific early and late replication domains have been discovered throughout genomes by analysis of DNA from populations of cells. However, cell to cell differences and the association of these differences with...
ORGANISM(S): Homo sapiens 
2013-01-08 | E-GEOD-41777 | biostudies-arrayexpress
TranscriptomicsIdentification of DNA-replication domains in single S-phase cells: part 2 multi-cell controls
DNA-replication is a key process in life and can lead to disease when disturbed. Cell-type specific early and late replication domains have been discovered throughout genomes by analysis of DNA from populations of cells. However, cell to cell differences and the association of these differences with...
ORGANISM(S): Homo sapiens 
2013-01-08 | E-GEOD-38757 | biostudies-arrayexpress
TranscriptomicsIdentification of DNA-replication domains in single S-phase cells: part 1 whole genome amplified single-cell DNA
DNA-replication is a key process in life and can lead to disease when disturbed. Cell-type specific early and late replication domains have been discovered throughout genomes by analysis of DNA from populations of cells. However, cell to cell differences and the association of these differences with...
ORGANISM(S): Homo sapiens 
2013-01-08 | E-GEOD-38758 | biostudies-arrayexpress
TranscriptomicsIdentification of DNA-replication domains in single S-phase cells: part 2 whole genome amplified single-cell
DNA-replication is a key process in life and can lead to disease when disturbed. Cell-type specific early and late replication domains have been discovered throughout genomes by analysis of DNA from populations of cells. However, cell to cell differences and the association of these differences with...
ORGANISM(S): Homo sapiens 
2013-01-08 | E-GEOD-38759 | biostudies-arrayexpress
TranscriptomicsIdentification of DNA-replication domains in single S-phase cells: part 1 multi-cell controls
DNA-replication is a key process in life and can lead to disease when disturbed. Cell-type specific early and late replication domains have been discovered throughout genomes by analysis of DNA from populations of cells. However, cell to cell differences and the association of these differences with...
ORGANISM(S): Homo sapiens 
2013-01-08 | E-GEOD-38756 | biostudies-arrayexpress
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