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TranscriptomicsMechanistic evaluation of the insulin response in H4IIE hepatoma cells: New endpoints for toxicity testing?
Transcriptional profiling of insulin exposed H4IIE cells at different time points (6h-24h) to 100 nM insulin, with untreated solvent control cells (blanks). The central role of hepatic insulin resistance in pandemic metabolic diseases urges investigation of the underlying mechanisms of its developme...
ORGANISM(S): Rattus norvegicus 
2012-06-17 | E-GEOD-35697 | biostudies-arrayexpress
TranscriptomicsMechanistic analysis of the model obesogen Tributyltin in the 3T3-L1 cell line
Obesogenic compounds are chemicals that might have an influence on obesity development through in utero or chronic lifetime exposure. Tributyltin (TBT) is one of the most studied obesogenic compounds, inducing adipogenesis in vitro and increasing body fat after in utero exposure of mice. This study ...
ORGANISM(S): Mus musculus 
2013-02-25 | E-GEOD-41340 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of 8Br-cAMP treated human H295R adrenal cortex
Transcriptional profiling of 8Br-cAMP exposed H295R cells at different time points (10h-24h-48h) and different concentrations (50uM-100uM-300uM) with untreated solvent control cells (blanks) Analysed on a H295R custom microarray, referred to as platform GPL9718 common reference design (pool of contr...
ORGANISM(S): Homo sapiens 
2011-11-15 | E-GEOD-32926 | biostudies-arrayexpress
TranscriptomicsToxicogenomics in the 3T3-L1 cell line, a new approach for screening of obesogenic compounds
The obesogen hypothesis states that exposure to environmental compounds early in life or throughout lifetime might have an influence on obesity development. In this paper a new approach for obesogen screening is proposed, namely the use of transcriptomics in the 3T3-L1 pre-adipocyte cell line. Based...
ORGANISM(S): Mus musculus 
2014-05-01 | E-GEOD-53004 | biostudies-arrayexpress
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