Vargas Gabriela Coronel GC

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Proteomics (2)

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Alphavirus (2)
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Brassica oleracea var. oleracea (2)
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Nostoc sp. PCC 7120 = FACHB-418 (2)
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pride (2)

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Disease

Alexander disease (1)

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Mass Spectrometry (2)
Bottom-up proteomics (1)
Data-dependent acquisition (1)
Shotgun proteomics (1)

Publication Date

2025 (2)

Lab affiliation

Department Neurobiology and Molecular Medicine, IRCCS Fondazione Stella Maris, 56128 Pisa, Italy (1)
U.O. Proteomica e Spettrometria di Massa Centro Biotecnologie Avanzate (CBA) IRCCS Ospedale Policlinico San Martino, Genova, Italiy (1)

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Long-Term Benefits of TUDCA Supplement in ARSACS Zebrafish Model

Our work demonstrated an impairment in cognitive, social and emotional behavior in aged sacs knockout zebrafish similar to that observed in human patients. Transcriptomic and proteomic data from the adult brains revealing alterations in several genes related to circadian rhythms and neuroinflammatio...

ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio)

2025-09-03 | PXD058522 | Pride

Multiomics approaches in Alexander disease zebrafish model show correlation between GFAP aggregation, altered lipid metabolism and oxidative stress

In this work we used our zebrafish model of Alexander Desease (AxD), aiming at unraveling the main pathways involved in AxD pathogenesis performing the first multi-omics analysis on a in vivo model of AxD. The obtained results have been functionally validated and they open the way to further investi...