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ProteomicsAnalysis of human brain tissue derived from DBS surgery
The implantation of deep brain stimulation (DBS) electrodes into the human brain is a neurosurgical treatment for, e.g., movement disorders. We describe a novel approach to collecting brain tissue from DBS surgery-guiding instruments for liquid chromatography-mass spectrometry and RNA sequencing ana...
ORGANISM(S): Homo sapiens (Human) 
2021-06-29 | PXD026936 | Pride
Human Brain Deep brain stimulation 
ProteomicsMAC-TAG Helios point mutations and wildtype BioID-MS
BioID-MS of Helios point mutations and wildtype, all MAC-tagged C-terminally. Included mutations: I325V M301K R106W R291X L328F WT V347M Y359C Y200C P18S N220S Analysis was performed on a Q-Exactive mass spectrometer with an EASY-nLC 1000 Liquid Chromatograph Q Exactive Hybrid Quadrupole-Orbitrap ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000088165 | MassIVE
ProteomicsAutomated MagNet Enrichment Unlocks Deep and Cost-Effective LC-MS Plasma Proteomics
Plasma is an ideal material for proteomics due to its diverse protein content reflecting physiological and pathological states, and its compatibility with minimally invasive sampling. Deep proteomic profiling of plasma is limited by high-abundant proteins that mask the detection of low-abundant prot...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-05-05 | MSV000097796 | MassIVE
UnknownRNAseq and LC-MS datasets from human brain tissue derived from DBS surgery
Not available
ORGANISM(S): Homo sapiens (human) 
S-BSST667 | biostudies-other
GenomicsOncogenic Herpesvirus utilizes stress-induced cell cycle checkpoints for efficient lytic replication.
ChIP-sequencing reads from Oncogenic Herpesvirus utilizes stress-induced cell cycle checkpoints for efficient lytic replication, accepted to PLOS Pathogens
ORGANISM(S): Homo sapiens 
2016-06-01 | E-MTAB-4356 | biostudies-arrayexpress
ProteomicsColonic metaproteomic signatures of active bacteria and the host in obesity
Colonic metaproteomic signatures of active bacteria and the host in obesity
ORGANISM(S): Metaproteome 
2015-08-15 | MSV000079242 | MassIVE
ProteomicsSARSCoV2 host proteome interactions for antiviral drug discovery
We adopted the MAC (Multiple Approaches Combined) tag system enabling both APMS and BioIDMS analysis with a single construct to perform a comprehensive analysis to map SARSCoV2 host interactome.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-11 | MSV000087035 | MassIVE
ProteomicsModeling FSHR function with hPSCs
Follicle-stimulating hormone (FSH) is crucial in the development and regulation of reproductive functions. We expressed MAC-tagged FSH receptor (FSHR) in HEK293 cells followed by affinity purification mass spectrometry analyses, to investigate interactome of FSHR at resting state and upon FSH stimul...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-17 | MSV000088577 | MassIVE
ProteomicsComprehensive Dynamic Interaction Landscape of the Mammalian Hh Signaling Pathway
The Hedgehog (Hh) signaling pathway is essential for embryonic development and tissue homeostasis, and its dysregulation contributes to severe developmental disorders and various cancers. Despite its biological importance, a detailed understanding of the dynamic interactions and phosphorylation even...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2025-03-17 | MSV000097352 | MassIVE
ProteomicsA splice-site variant in MADD affects hormone expression in pancreatic b-cells and pituitary gonadotropes
MADD is a multifunctional protein regulating activation and localization of small GTP-binding proteins RAB3 and RAB27, MAPK-signaling and cell survival. Polymorphisms in MADD locus have been associated with glycemic traits, but patients with bi-allelic variants in MADD manifest complex syndrome af...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-06 | MSV000093584 | MassIVE
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