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TranscriptomicsHypothalamic gene expression profile indicates a reduction in G-protein signaling in the wfs1 mutant mice
WFS1 gene is coding protein with unknown function but its functional deficiency causes different neuropsychiatric and neuroendocrine syndromes. In the present study we aimed to find the functional networks influenced by the Wfs1 deficiency in the hypothalamus. We performed gene expression profiling ...
ORGANISM(S): Mus musculus 
2011-11-02 | E-GEOD-33372 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse cholecystokinin b receptor (Cckbr)-deficient mice after chronic constriction injury
The cholecystokinin B (2) receptor knockout (Cckbr KO) protects against allodynia induced by chronic constriction injury (CCI). The mechanism of this phenomenon is unknown, but must involve persistent changes in pain modulation and/or inflammatory pathways. We performed a gene expression study in tw...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9594 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of temporal lobes of wfs1 deficient mice
Aim of present study was to describe the changes induced deletion of the Wfs1 gene in the temporal lobe of mice. Mutant mice were backcrossed to two different genomic backgrounds in order to exclude confounding foreign genomic background influence. Samples from temporal lobes were analyzed by using ...
ORGANISM(S): Mus musculus 
2010-04-06 | E-GEOD-15293 | biostudies-arrayexpress
TranscriptomicsTissue culture model of hypoxia
Validation of an in vitro model of hypoxia using a primary cell culture of mouse embryonic fibroblasts (MEF) exposed to 1% oxygen at 37 degrees celsius. Control cells were exposed to atmospheric oxygen. Hypoxic and normoxic MEF (in 100 mm dishes, four replicates per group) were submitted to gene exp...
ORGANISM(S): Mus musculus 
2014-03-01 | E-GEOD-54228 | biostudies-arrayexpress
TranscriptomicsTissue culture model of hypothermia
Therapeutic hypothermia is a clinically effective treatment for various hypoxic and ischemic conditions, but the associated molecular mechanisms remain unclear. To gain insight into hypothermia-induced transcriptional response, mouse embryonic fibroblasts were exposed to mild hypothermia (32°C) or ...
ORGANISM(S): Mus musculus 
2014-03-01 | E-GEOD-54229 | biostudies-arrayexpress
TranscriptomicsEffect of chronic valproic acid treatment on hepatic gene expression profile in Wfs1 knockout mouse.
Aim of the present study was to compare the effect of chronic VPA treatment in wild type and Wfs1 knockout mice on hepatic gene expression profile. Wild type, Wfs1 heterozygous and homozygous mice were treated with VPA for three months (300 mg/kg i.p. daily) and gene expression profiles in liver wer...
ORGANISM(S): Mus musculus 
2014-02-20 | E-GEOD-55143 | biostudies-arrayexpress
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