Vascular biology

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Organisms

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synthetic construct (1)
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Organisms

Homo sapiens (248)
Mus musculus (235)
Arabidopsis thaliana (34)
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Macaca mulatta (3)
Solanum lycopersicum (3)
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Mus (1)
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Marchantia polymorpha (1)
Gallus gallus (1)
Glycine max (1)

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Tissue

Cell culture (14)
Blood plasma (10)
Heart (7)
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Liver (5)
Aorta (4)
Endothelial cell (3)
Endothelial cell of umbilical vein (3)
Plant cell (3)
Brain (3)
Epithelial cell (3)
Whole body (3)
Pancreatic endocrine cell (2)
Endothelial cell of vascular tree (2)
Arterial system endothelium (2)
Vascular associated smooth muscle cell (2)
Seedling (2)
Adipose tissue (2)
Blood platelet (2)
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Root (2)
Blood cell (2)
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Brain vascular cell (1)

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Not Available (1)
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Lyme disease (1)
Hydrocephalus (1)
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Pulmonary hypertension (1)
Aortic valve stenosis (1)
Multiple sclerosis (1)

Technology Type

Mass Spectrometry (111)
Shotgun proteomics (53)
Bottom-up proteomics (27)
Data-dependent acquisition (12)
Data-independent acquisition (11)
Mass spectrometry (8)
Affinity purification coupled with mass spectrometry proteomics (8)
Mass spectrometry assay (5)
Gel-based experiment (3)
SWATH MS (3)
NMR spectroscopy (2)
Olink affinity proteomics (2)
Affinity proteomics (2)
HDMSE (2)
Top-down proteomics (2)
MSE (1)
Mass spectrometry imaging (1)
DiaPASEF (1)
All-ion fragmentation (1)

Instrument Platform

Illumina NovaSeq 6000 (8)
Illumina HiSeq 4000 (8)
NextSeq 500 (8)
LTQ Orbitrap Velos (8)
Illumina HiSeq 2500 (7)
NextSeq 2000 (5)
Illumina HiSeq 2000 (5)
Q Exactive (5)
Qiagen-Qiacube (2)
Affymetrix GeneChip Scanner 3000 7G (2)
DNBSEQ-G400 (2)
Illumina MiSeq (2)
Orbitrap Exploris 480 (2)
LTQ Orbitrap XL (2)
Chromium Next GEM Chip G (1)
Single-Cell Extraction: For enzymatic digestion, pronase (Septomyces argeus, 1 mg/mL) was applied for 25 minutes at room temperature for P0 to P8 datasets. Cells were dissociated and triturated into a single-cell suspension in ACSF supplemented with 1% fetal calf serum (FCS) and DNase (1 µL/10 mL). Trituration was performed using three glass Pasteur pipettes of decreasing diameters. For P30 datasets, enzymatic digestion and cell dissociation were carried out using the Worthington Papain Dissociation System, following the manufacturer’s instructions. Single-Nuclei Extraction: For nuclei isolation, the Hibernate™-E Medium was removed, and 500 µL of chilled 0.1X NP40 Lysis Buffer was added. Tissue was homogenized using a Pellet Pestle (15 strokes) and incubated on ice for 5 minutes. The suspension was pipette-mixed 10 times using a wide-bore pipette tip and incubated for an additional 10 minutes on ice. Following lysis, 500 µL of chilled wash buffer was added, and the mixture was pipette-mixed 5 times using a regular-bore pipette tip. The suspension was filtered through a 30 µm cell strainer into a 50 mL tube to remove debris. The filtered suspension was transferred to a 1.5 mL tube and centrifuged at 950 × g for 10 minutes at 4°C. The supernatant was carefully removed, and the nuclei pellet was retained for downstream analysis. (1)
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Do not apply (1)
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418 [Affymetrix] (1)
Illumina Genome Analyzer II (1)
Axon GenePix 4000B scanning hardware (1)
Illumina NovaSeq X (1)
NA (1)
DNBSEQ-T7 (1)
Instrument (1)

Publication Date

2010 (72)
2014 (65)
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2015 (62)
2016 (52)
2026 (50)
2024 (45)
2012 (43)
2023 (41)
2011 (38)
2008 (37)
2013 (35)
2009 (30)
2022 (26)
2021 (25)
2020 (24)
2018 (20)
2019 (16)
2007 (13)
2017 (12)
2006 (7)
2005 (4)
2004 (1)

UNIPROT ID/AC

Q03135 (3)
P31749 (3)
P08238 (2)
Q9Y5W3 (2)
Q15119 (2)
O14733 (2)
P01112 (2)
Q05397 (2)
P62158 (2)
O15530 (2)
Q13233 (2)
Q07889 (2)
P29353 (2)
P60484 (2)
P45983 (2)
P12931 (2)
P62993 (2)
Q8IIK9_PLAF7 (2)
Q8ILI7_PLAF7 (2)
O96219_PLAF7 (2)
Q8I482_PLAF7 (2)
Q940Y5 (1)
Q9S7Z8 (1)
Q9LTS3 (1)
O04291 (1)
Q9SB04 (1)
P49678 (1)
Q9SSC9 (1)
Q9SL42 (1)
Q96247 (1)

ENSEMBL ID

ENSG00000204131 (2)
ENSG00000229353 (2)
ENSG00000147251 (2)
ENSG00000247315 (2)
ENST00000297494 (1)
ENSMUSG00000027651 (1)
ENSMUSG00000072849 (1)
ENSMUSP00000141097 (1)
ENSG00000170477 (1)

CHEBI ID

CHEBI:29108 (3)
CHEBI:203600 (2)
CHEBI:57600 (2)
CHEBI:18348 (2)
CHEBI:16480 (2)
CHEBI:17552 (2)
CHEBI:17084 (2)
CHEBI:16708 (2)
CHEBI:23530 (1)
CHEBI:16467 (1)
CHEBI:24287 (1)
CHEBI:133632 (1)
CHEBI:133639 (1)
CHEBI:133627 (1)
CHEBI:718061 (1)
CHEBI:131364 (1)
CHEBI:41609 (1)
CHEBI:77468 (1)
CHEBI:69188 (1)
CHEBI:133083 (1)
CHEBI:33980 (1)
CHEBI:22194 (1)
CHEBI:34117 (1)
CHEBI:28309 (1)
CHEBI:4139 (1)
CHEBI:48300 (1)
CHEBI:17123 (1)
CHEBI:16125 (1)
CHEBI:33954 (1)
CHEBI:22357 (1)

Metabolite Name

3-Phosphoadenylylselenate (2)
Vincristine (2)
Rimexolone (2)
Psychosine sulfate (2)
3-Methyluric acid (2)
Indoleacetaldehyde (2)
Gamma-Glutamylcysteine (2)
1-Hydroxy-2-naphthoic acid (2)
Methionine (2)
Alpha-Tocotrienol (2)
L-Erythrulose (2)
D-Urobilin (2)
Glycitein (2)
Prunasin (2)
Anserine (2)
D-Ribulose 5-phosphate (2)
6-Phosphogluconic acid (2)
Xanthosine (2)
Taurine (2)
3-(3-Hydroxyphenyl)propanoic acid (2)
Indole-3-carboxaldehyde (2)
Pyrrole-2-carboxylic acid (2)
Hypoxanthine (2)
Creatine (2)
Adenine (2)
Itaconic acid (2)
Prostaglandin E2 (2)
L-Threonine (2)
L-Tryptophan (2)
L-Glutamine (2)

First Public Date

2014 (127)
2025 (92)
2026 (83)
2024 (60)
2023 (60)
2021 (53)
2020 (48)
2019 (48)
2022 (38)
2015 (29)
2018 (22)
2017 (16)
2016 (6)
2013 (6)
2012 (1)

Modelling Approach

Ordinary differential equation model (7)

Study status

Completed (1)

Lab affiliation

VIB-UGent Center for Plant Systems Biology (2)
The Center for Excellence in Vascular Biology, Cardiovascular Division The Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA (2)
Department of Biochemistry and Molecular Biology, University of Calgary, Alberta, Canada; Department of Physiology and Pharmacology, University of Calgary, Alberta, Canada; The Hotchkiss Brain Institute, University of Calgary, Alberta, Canada; McCaig Institute for Bone and Joint Health, University of Calgary, Alberta, Canada (2)
Vascular Biology Center, Augusta University (1)
Department of Biology, York University, Toronto, Ontario, Canada (1)
Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany (1)
Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil (1)
Professor, Department of Biochemistry and Molecular Biology, University of Southern Denmark (SDU), Denmark (1)
Washington University in St. Louis - School of Medicine Division of Endocrinology, Metabolism & Lipid Research (1)
Department of Cell- and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria (1)
Department of Neurology and Neurological Sciences, Stanford University, United States (1)
Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Greece (1)
Institute of Cellular Biology and Pathology "Nicolae Simionescu" (1)
Max Planck Institut for Molecular Biomedicine Bioanalytical Mass Spectromentry Röntgenstr. 20 48149 Münster, Germany (1)
Department of Plant Molecular Biology, University of Lausanne, Biophore Building, DBMV, CH-1015 Lausanne, Switzerland (1)
Centro Nacional de Investigaciones Cardiovasculares, 28029, Madrid, Spain (1)
Labo Pathophysiology, Department of Biomedical Sciences, University of Antwerp. Belgium (1)
Unit of functional proteomic, metabolomi and network analysis, Centro Cardiologico Monzino IRCCS, Milan, Italy (1)
Vascular Biology Group, Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark. (1)
Laboratory of Biochemistry and Vascular Biology Center for Biologics Evaluation and Research Food and Drug Administration (1)
Department of Molecular Biolgy, Princeton University, USA (1)
Professor and Deputy Director, Center for Systems Biology and Molecular Medicine Yenepoya Research Centre Yenepoya (Deemed to be University) University Road, Deralakatte Mangalore 575018, India Phone: 0824-2204668 (Ext:2057) Email:csbmm@yenepoya.edu.in (1)
Department of Biochemistry and Molecular Biology, College of Basic Medicine, Key Laboratory of Medical Biotechnology of Hebei Province, Hebei Medical University, Shijiazhuang, China (1)
Department of Pathogen Biology, School of Clinical and Basic Medicine, Shandong First Medical University &Shandong Academy of Medical Sciences (1)
Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig-Maximilians-University (LMU) Munich, Germany. (1)
Division of Vascular Oncology and Metastasis Research,German Cancer Research Center (DKFZ), Heidelberg, Germany. European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. (1)
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin 300353, People’s Republic of China (1)
Department of Plant Biotechnology and Bioinformatics, Ghent University; 9052 Ghent, Belgium; Center for Plant Systems Biology, VIB; 9052 Ghent, Belgium (1)
Department of Pathology and Medicine, University of California at San Diego, La Jolla, CA 92093, USA (1)
Department of Immunology and Regenerative Biology The Weizmann Institute of Science (1)

Keyword

Patients with metastatic colorectal cancer who did not receive (1)
Systemic treatment for their metastatic disease (1)
Irinotecan (1)
Capecitabine (1)
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Oxaliplatin (1)

IsPrivate

False (7)

Modification

4-tetrahydrothiazine-3-carboxylic acid (1)

Study type

Transcription profiling by array (266)
RNA-seq of coding RNA (56)
ChIP-chip by tiling array (17)
RNA-seq of coding RNA from single cells (12)
ChIP-seq (10)
RNA-seq of non coding RNA (9)
Other (8)
Unknown experiment type (6)
Comparative genomic hybridization by array (6)
Proteomic profiling by array (5)
Methylation profiling by array (4)
RNA-seq of total RNA (3)
Cell line - High-throughput sequencing (2)
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DNA-seq (2)
Methylation profiling by high throughput sequencing (2)
Cell line - Single-cell sequencing (1)
Human - High-throughput sequencing (1)
Plant - High-throughput sequencing (1)
High-throughput sequencing (1)
Animal - High-throughput sequencing (1)
Proteomic profiling by mass spectrometer (1)
Transcription profiling by tiling array (1)
ChIP-chip by array (1)
Genotyping by array (1)
CLIP-seq (1)
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Interventional (1)

Release Date

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2019 (1175)
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2017 (1001)
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2013 (620)
2012 (611)
2011 (536)
2010 (466)
2009 (413)
2008 (327)
2026 (212)
2007 (168)
2006 (108)
2005 (56)
2004 (49)
2003 (38)
2002 (20)
2001 (19)
2000 (17)
1998 (10)
1999 (4)
1997 (2)

Location

Austria (1)

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Genetic Framework for GATA Factor Function in Vascular Biology

Vascular endothelial dysfunction underlies the genesis and progression of numerous diseases. Whereas the GATA transcription factor GATA-2 is expressed in endothelial cells and is implicated in coronary heart disease, it has been studied predominantly as a master regulator of hematopoiesis. As many q...

ORGANISM(S): Homo sapiens

2011-08-11 | E-GEOD-29531 | biostudies-arrayexpress

Differential endothelial cell gene expression by African Americans versus Caucasian Americans: A possible contribution to health disparity in vascular disease and cancer

Background: African Americans (AA) have increased burdens of cardiovascular disease and cancer compared to Caucasian Americans (CA). This study addresses the possibility that genetic differences affecting the biology of the vascular endothelium could be a factor contributing to this health disparity...

ORGANISM(S): Homo sapiens

2010-07-02 | E-GEOD-22688 | biostudies-arrayexpress

Lysolipids in Vascular Development, Biology, and Disease.

Not available

S-EPMC8105276 | biostudies-literature

High-throughput sequencing of endogenous small RNAs from rat vascular smooth muscle cells with and without Angiotensin II stimulation

Angiotensin II (Ang II)-mediated vascular smooth muscle cells (VSMC) dysfunction plays a critical role in cardiovascular diseases. However, the role of microRNAs (miRNAs) in this process is unclear. We used small RNA deep sequencing to profile Ang II-regulated miRNAs in rat VSMC and evaluated their ...

ORGANISM(S): Rattus norvegicus

2012-03-23 | E-GEOD-35664 | biostudies-arrayexpress

MIGen_ExS: Italian Atherosclerosis Thrombosis and Vascular Biology

Italian Atherosclerosis Thrombosis and Vascular Biology study is a prospective, nationwide, case-control study involving 125 coronary care units in Italy. The cases were patients who were hospitalised for a first MI before the age of 45 years and underwent coronary angiography. Acute MI was defin...

phs000814 | dbGaP

Vascular properties of breast cancer intrinsic subtypes

Interactions of cancer cells with the vasculature are essential for tumor growth and likely promote metastatic progression. Endothelial cell content and lympho-vascular invasion are generally associated with tumor aggressiveness, however, these features are generally not employed in the clinic. We a...

ORGANISM(S): Homo sapiens

2014-01-01 | E-GEOD-37145 | biostudies-arrayexpress

Center for Common Disease Genomics [CCDG] - Cardiovascular ATVB: Atherosclerosis Thrombosis and Vascular Biology

phs001592 | dbGaP

Vascular histone deacetylation by pharmacological HDAC inhibition [SAHA, RNA-seq]

HDAC inhibitors are thought to regulate gene expression by post-translational modification of histone as well as non-histone proteins. Often studied at single loci, increased histone acetylation is the paradigmatic mechanism of action, however, little is known of the extent of genome-wide changes of...

ORGANISM(S): Homo sapiens

2014-02-23 | E-GEOD-54912 | biostudies-arrayexpress

Vascular histone deacetylation by pharmacological HDAC inhibition [TSA, RNA-seq]

ORGANISM(S): Homo sapiens

2014-02-23 | E-GEOD-37376 | biostudies-arrayexpress

Muraro2014 - Vascular patterning in Arabidopsis roots

Muraro2014 - Vascular patterning in Arabidopsis roots Using a multicellular model, maintanence of vascular patterning in Arabidopsis roots has been studied. The model that is provided here is the single-cell version of the model. The two-cell and multicellular models described in t...

2024-09-02 | BIOMD0000000522 | BioModels

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