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MetabolomicsOverexpression of the vascular brassinosteroid receptor BRL3 confers drought resistance without penalizing plant growth

Drought represents a major threat to food security. Mechanistic data describing plant responses to drought have been studied extensively and genes conferring drought resistance have been introduced into crop plants. However, plants with enhanced drought resistance usually display lower growth, hi...

2021-05-17 | MTBLS2289 | MetaboLights
MetabolomicsAnti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 10)

Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia inducible f...

2021-07-22 | MTBLS3056 | MetaboLights
MetabolomicsAnti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 21)

Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia inducible f...

2021-07-22 | MTBLS3003 | MetaboLights
MetabolomicsThe mechanism of vascular injury caused by polystyrene microplastics: A molecular toxicology study involving ferroptosis and metabolomics

Background: Polystyrene microplastics (PS-MPs) are degradation products of plastics that are prevalent in the environment. Recent studies have established a significant correlation between exposure to PS-MPs and the incidence of cardiovascular diseases (CVD). Objective: This study aims to investi...

2026-08-16 | MTBLS14514 | MetaboLights
ProteomicsDeep learning neural network prediction method improves proteome profiling of vascular sap of grapevines during Pierces disease development
Plant secretome studies have shown the importance of plant defense proteins in the vascular system against pathogens. Studies on Pierces disease of grapevines caused by the xylem-limited bacteria Xylella fastidiosa Xf have detected proteins and pathways associated to its pathobiology. Despite the bi...
ORGANISM(S): Vitis Vinifera (ncbitaxon:29760) Xylella Fastidiosa Temecula1 (ncbitaxon:183190) 
2020-08-12 | MSV000085942 | MassIVE
MetabolomicsMulti-kingdom gut microbiota dysbiosis is associated with the development of pulmonary arterial hypertension

Gut microbiota dysbiosis has been implicated in pulmonary arterial hypertension (PAH). However, most studies have focused on the bacterial community and the exact role and mechanisms of multi-kingdom gut microbiota, including bacteria, archaea and fungi in PAH remains largely unclear. Idiopathic ...

2025-05-12 | MTBLS10563 | MetaboLights
MetabolomicsMetabolic balancing by miR-276 shapes the mosquito reproductive cycle and Plasmodium falciparum development
The blood-feeding behavior of Anopheles females delivers essential nutrients for egg development and drives parasite transmission between humans. Plasmodium growth is adapted to the vector reproductive cycle, but how changes in the reproductive cycle impact parasite development remains unclear. Here...
2021-11-03 | MTBLS1282 | MetaboLights
TranscriptomicsTranscriptomic analysis reveals novel long non-coding RNAs critical for vertebrate development [RNA-Seq]
Long non-coding RNAs (lncRNAs) have emerged as critical regulators of gene expression and chromatin modifications, with important functions in development and disease. Here we sought to identify and functionally characterize lncRNAs critical for vascular vertebrate development with significant conse...
ORGANISM(S): Homo sapiens 
2015-05-15 | E-GEOD-54968 | biostudies-arrayexpress
ProteomicsExtracellular peptide Kratos restricts cell death during vascular development and stress in Arabidopsis
During plant vascular development, xylem tracheary elements (TEs) form water conducting, empty pipes through genetically regulated cell death. Cell death is prevented from spreading to non-TEs by unidentified intercellular mechanisms, downstream of METACASPASE9 (MC9)-mediated regulation of autophagy...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-01-31 | PXD010886 | Pride
Arabidopsis Vascular development Tracheary element Peptidomics Extracellular Cell death Metacaspase9 
TranscriptomicsGenome-wide analysis reveals dynamic changes in microRNAs expression during vascular cambium development in Chinese fir
MicroRNAs (miRNAs) are small noncoding regulatory RNAs that play key roles in the process of plant development. To date, extensive studies of miRNAs have been performed in a few model plants, but few efforts have focused on small RNAs in conifers because of the lack of reference sequences for these ...
ORGANISM(S): Cunninghamia lanceolata 
2015-04-07 | E-GEOD-53933 | biostudies-arrayexpress
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