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TranscriptomicsAnalysis of transcriptome in ectopic versus orthotopic thyroid tissue.
Congenital hypothyroidism from thyroid dysgenesis (CHTD) is a sporadic disease characterized by defects in the differentiation, migration or growth of thyroid tissue. Of these defects, incomplete migration resulting in ectopic thyroid tissue is the most common (up to 80%). We obtained flashfrozen sa...
ORGANISM(S): Homo sapiens 
2010-10-28 | E-GEOD-16804 | biostudies-arrayexpress
TranscriptomicsMethylome analysis of congenital ectopic thyroids
To assess whether specific genes have relevant somatic genetic or epigenetic alterations in ectopic tissue, we used a combined analysis of transcriptome (confirmed by qRT-PCR on 68 genes), methylome, structural genome variations (copy number variants, CNVs) and miRNA profile of ectopic compared with...
ORGANISM(S): Homo sapiens 
2010-10-27 | E-GEOD-17581 | biostudies-arrayexpress
TranscriptomicsSomatic CNV profile of congenital ectopic thyroids
To assess whether specific genes have relevant somatic genetic or epigenetic alterations in ectopic tissue, we used a combined analysis of transcriptome (confirmed by qRT-PCR on 68 genes), methylome, structural genome variations (copy number variants, CNVs) and miRNA profile of ectopic compared with...
ORGANISM(S): Homo sapiens 
2010-10-27 | E-GEOD-17463 | biostudies-arrayexpress
TranscriptomicsIdentification of Lgr5-independent spheroid-generating progenitors of the mouse fetal intestinal epithelium
Immortal spheroids were generated from fetal mouse intestine using the culture system developed to culture organoids from adult intestinal epithelium. Spheroids are made of a monostratified polarized epithelium displaying a poorly differentiated intestinal phenotype. The proportion of spheroids gene...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-49803 | biostudies-arrayexpress
TranscriptomicsLgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells
Gene inactivation of the orphan G protein-coupled receptor Lgr4, a paralog of the epithelial stem cell marker Lgr5, results in 50% decrease of epithelial cell proliferation and 80% reduction in terminal differentiation of Paneth cells in postnatal mouse intestinal crypts. When cultured ex vivo, Lgr4...
ORGANISM(S): Mus musculus 
2012-03-10 | E-GEOD-27904 | biostudies-arrayexpress
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