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ProteomicsPTM-MS of KRASi treated pNF cells
The goal of the study was to profile the effects of KRAS inhibition in peripheral neuron cells. Phosphoproteomics was performed to profile global changes in phosphorylation after treatment with BI-2865.
ORGANISM(S): Homo sapiens (Human) 
2025-06-17 | PXD061467 | Pride
Phosphoproteomics Peripheral neuron cells Mek 
ProteomicsProximity labeling of NF1 using APEX
The goal of the study was to profile protein interaction neighborhood of NF1 by expressing NF1-APEX and profiling biotinylated proteins in proximity of NF1. Interactions were assessed at basal conditions or in the context of MEK inhibition with selumetinib.
ORGANISM(S): Homo sapiens (Human) 
2025-06-17 | PXD064557 | Pride
Apex Nf1 Selumetinib 
ProteomicsPTM-MS of MEKi treated sgNF1 iPN cells
The goal of the study was to profile the effects of MEK inhibition in iPN cells or control sgNTC iPN cells. Phosphoproteomics was performed to profile global changes in phosphorylation after treatment with selumetinib.
ORGANISM(S): Homo sapiens (Human) 
2025-06-17 | PXD064434 | Pride
Ipn Nf1 Selumetinib 
ProteomicsVestibular schwannoma is comprised of neural crest and immune subgroups
Vestibular schwannomas (VS) are tumors arising from cranial nerve Schwann cells that cause significant morbidity and are treated with surgery and irradiation. We describe a DNA methylation-based classification of VS into neural crest and immune enriched subgroups and validate our findings using bulk...
ORGANISM(S): Homo Sapiens 
PXD014883 | panorama
UnknownSARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.
SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at...
S-EPMC8652887 | biostudies-literature
UnknownTiming of surgery following SARS-CoV-2 infection: an international prospective cohort study.
Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing ele...
S-EPMC8206995 | biostudies-literature
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