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ProteomicsThe E3 ubiquitin ligase RNF25 protects stalled DNA replication forks
Cancer cells experience high levels of replication stress and have therefore adapted mechanisms to tolerate replication stress. Using a CRISPR screen, we identified RNF25 as a mediator of replication stress tolerance in cancer cells. RNF25-ablation results in ssDNA accumulation, decreased replicatio...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD056698 | Pride
Cell culture Ip-ms Homo sapiens 
ProteomicsDeciphering TRIM69 interactors and its phosphor-proteomic regulation in centrosome dynamics
Stringent control of centrosome duplication and separation is important for preventing chromosome instability. Structural and numerical alterations in centrosomes are hallmarks of neoplastic cells and contribute to tumorigenesis. We show that a Centrosome Amplification 20 (CA20) gene signature is a...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042098 | Pride
Kgg Centrosome dynamics Phosphoproteomic profiling Ip mass-spectrometry 
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