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ProteomicsIdentification of SUMO targets required to maintain human stem cells in the pluripotent state. - Characterisation of 6His-SUMO-KGG-mCherry ChiPS4 cells
To determine the role of SUMO modification in the maintenance of pluripotent stem cells we used ML792, a potent and selective inhibitor of SUMO Activating Enzyme. Treatment of human induced pluripotent stem cells with ML792 initiated changes associated with loss of pluripotency such as reduced expre...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD023241 | Pride
Sumo Stem cells Ml792 
UnknownKGG: a fully automated workflow for creating disease-specific knowledge graphs.
Not available
S-EPMC12270262 | biostudies-literature
UnknownKGG: Knowledge-Guided Graph Self-Supervised Learning to Enhance Molecular Property Predictions.
Not available
S-EPMC12458709 | biostudies-literature
ProteomicsAnalysis of the ubiquitinated peptides using the yeast Rpt2-normal, G2A and G2delta strains
Ubiquitinated peptides (KGG peptides) purified from the yeast strains with or without mutation on the N-myristoylation site of the proteasome Rpt2 subunit were analyzed by an LTQ-Orbitrap Velos. The MS data was analyzed by the Progenesis LC-MS software.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-08-25 | PXD002274 | Pride
Yeast Proteasome Ubiquitin Lc-ms/ms 
ProteomicsIdentification of SUMO targets required to maintain human stem cells in the pluripotent state. - Identification of SUMO modified proteins from hiPS cells
To determine the role of SUMO modification in the maintenance of pluripotent stem cells we used ML792, a potent and selective inhibitor of SUMO Activating Enzyme. Treatment of human induced pluripotent stem cells with ML792 initiated changes associated with loss of pluripotency such as reduced expre...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD028050 | Pride
Sumo Hipsc Stem cells 
ProteomicsChanges to SUMO-modified proteome and total cellular proteome during EBV ractivation in AGS gastric carcinoma cells
To monitor changes to cellular and viral SUMO-modified proteins during EBV reactivation. SUMO1 and SUMO2 conjugates were studied using KGG mutant forms of SUMO and GG-K specific antibody enrichment of SUMO modified peptides. Time-points of 12h and 24h post-reactivation were monitored. Total cellular...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD034631 | Pride
Sumo epstein-barr virus ebvhuman herpes virus 4 hhv4 
ProteomicsStructural proteomics reveals that misfolded nascent proteins expose buried lysines for ubiquitination and rapid proteasomal degradation
In this study, we combine structural proteomics and time-resolved isotopic labeling to profile the modification sites, dynamics, and conformational properties of the human ubiquitinome.
ORGANISM(S): Homo sapiens (Human) 
2026-04-26 | PXD069668 | Pride
ProteomicsGID/CTLH E3 ligase complex control cell fate programs for sexual development of Plasmodium falciparum
Transmission of the malaria parasite Plasmodium falciparum requires the formation of specialised sexual cells called gametocytes. A hallmark of P. falciparum gametocyte development is its long duration, during which the parasite undergoes dramatic cellular remodelling including morphological, physio...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2026-01-25 | PXD048861 | Pride
ProteomicsGoncharov et al. Raw data files
Raw KGG ubiquitination MS data files for two biological replicate studies of Nod2 receptor activation +/- XIAP inhibition.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-01-03 | MSV000081881 | MassIVE
UnknownSite-specific identification and quantitation of endogenous SUMO modifications under native conditions.
Not available
S-EPMC5660086 | biostudies-literature
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