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ProteomicsIdentification of SUMO targets required to maintain human stem cells in the pluripotent state. - Total protein level changes in response to ML792 treatment
To determine the role of SUMO modification in the maintenance of pluripotent stem cells we used ML792, a potent and selective inhibitor of SUMO Activating Enzyme. Treatment of human induced pluripotent stem cells with ML792 initiated changes associated with loss of pluripotency such as reduced expre...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD025867 | Pride
Sumo Stem cells Ml792 
TranscriptomicsInfluence of SUMOylation on transcriptional signature of hIPSCs (ChiPS4) assessed by time-resolved RNA-seq in response to ML792 treatment
SUMOylation is thought to regulate chromatin structure and accessibility thus affecting gene expression. In order to assess these potential roles of SUMOylation in human pluripotent stem cells, ChiPS4 cells were treated with ML792 (selective SUMO E1 inhibitor) or DMSO (vehicle control) for the follo...
ORGANISM(S): Homo sapiens 
2022-12-01 | E-MTAB-9962 | biostudies-arrayexpress
GenomicsInfluence of SUMOylation on transcriptional signature of hIPSCs (ChiPS4) assessed by time-resolved RNA-seq in response to ML792 treatment
Influence of SUMOylation on transcriptional signature of hIPSCs (ChiPS4) assessed by time-resolved RNA-seq in response to ML792 treatment
PRJEB42228 | ENA
GenomicsInfluence of SUMOylation on chromatin structure in hIPSCs (ChiPS4) assessed by time-resolved ATAC-seq in response to ML792 treatment
Influence of SUMOylation on chromatin structure in hIPSCs (ChiPS4) assessed by time-resolved ATAC-seq in response to ML792 treatment
PRJEB42229 | ENA
ProteomicsChromatomes of GR and SUMO2/3 identified with RIME
We identified GR and SUMO2/3 chromatomes in B-cell acute leukemia cells (NALM6) and studied the impact of SUMOylation inhibition (SUMOi) on them utilizing small molecule inhibitor ML792. Chromatome members were identified with Rapid Immunoprecipitation Mass spectrometry of Endogenous proteins (RIME)...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051304 | Pride
Human Cancer Immunoprecipitation Mass spectrometry Chromatin 
TranscriptomicsInfluence of SUMOylation on chromatin structure in hIPSCs (ChiPS4) assessed by time-resolved ATAC-seq in response to ML792 treatment
SUMOylation is thought to regulate chromatin structure and accessibility thus affecting gene expression. In order to assess these potential roles of SUMOylation in human pluripotent stem cells, ChiPS4 cells were treated with ML792 (selective SUMO E1 inhibitor) or DMSO (vehicle control) for the follo...
ORGANISM(S): Homo sapiens 
2022-12-01 | E-MTAB-9961 | biostudies-arrayexpress
ProteomicsChromatome of AR and SUMO2/3 idenitified with RIME
We identifyied AR and SUMO2/3 chromatomes in castration-resistant prostate cancer cells (VCaP) and studied the impact on SUMOylation inhibition (SUMOi)on them utilizing small molecule inhibitor ML792. Chromatome members were identifyied with Rapid Immunoprecipitation Mass spectrometry of Endogenous ...
ORGANISM(S): Homo sapiens (Human) 
2024-08-08 | PXD039179 | Pride
Ar Sumoylation Rime Chromatome Bruker timstof pro 
ProteomicsIdentification of SUMO targets required to maintain human stem cells in the pluripotent state. - Characterisation of 6His-SUMO-KGG-mCherry ChiPS4 cells
To determine the role of SUMO modification in the maintenance of pluripotent stem cells we used ML792, a potent and selective inhibitor of SUMO Activating Enzyme. Treatment of human induced pluripotent stem cells with ML792 initiated changes associated with loss of pluripotency such as reduced expre...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD023241 | Pride
Sumo Stem cells Ml792 
UnknownUBA2 SUMOylates NQO1 and promotes the proliferation of hepatocellular carcinoma by modulating the MAPK pathway.
Not available
S-EPMC11462937 | biostudies-literature
UnknownIdentification of SUMO Targets Associated With the Pluripotent State in Human Stem Cells.
Not available
S-EPMC8604812 | biostudies-literature
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