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GenomicsRAR/RXR binding dynamics distinguishes pluripotency from differentiation-associated cis-regulatory elements
In mouse embryonic cells, a retinoic acid (RA) stimulation triggers a massive change of gene expression leading the pluripotent, proliferating cells to a lineage-specific differentiation process. The retinoic acid receptor (RAR) plays a key role in this response by inhibiting pluripotency-maintainin...
ORGANISM(S): Mus musculus 
2015-04-17 | E-GEOD-56893 | biostudies-arrayexpress
GenomicsT-cell factor 4 and β-catenin chromatin occupancies pattern zonal liver metabolism.
β-catenin signaling can be both a physiological and an oncogenic pathway in the liver. It controls compartmentalized gene expression, allowing the liver to ensure its essential metabolic function. It is activated by mutations in 20 to 40% of hepatocellular carcinomas with specific metabolic features...
ORGANISM(S): Mus musculus 
2014-01-18 | E-GEOD-35213 | biostudies-arrayexpress
UnknownLessons from two series by physicians and caregivers' self-reported data in DDX3X-related disorders.
Not available
S-EPMC10801341 | biostudies-literature
UnknownGenome sequencing for the diagnosis of intellectual disability as a paradigm for rare diseases in the French healthcare setting: the prospective DEFIDIAG study.
Not available
S-EPMC12495801 | biostudies-literature
UnknownSystematic analysis of snRNA genes reveals frequent <i>RNU2-2</i> variants in dominant and recessive developmental and epileptic encephalopathies.
Not available
S-EPMC12424890 | biostudies-literature
UnknownDominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruption.
Not available
S-EPMC12165858 | biostudies-literature
Unknown<i>PFMG2025</i>-integrating genomic medicine into the national healthcare system in France.
Not available
S-EPMC11910791 | biostudies-literature
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