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TranscriptomicsThe miR-126/VEGFR2 axis controls the innate response to pathogen-associated nucleic acids
microRNA-126 is a microRNA predominately expressed by endothelial cells and controls angiogenesis. Unexpectedly, we found that mice deficient in miR-126 have a major impairment in their innate response to pathogen-associated nucleic acids, as well as HIV, which results in more widespread cell infect...
ORGANISM(S): Mus musculus 
2013-11-24 | E-GEOD-51255 | biostudies-arrayexpress
ProteomicsLC-MSMS on mouse retina to investigate photoreceptor degeneration
Intraocular anti-VEGFA injections are frequently used to counteract neovascularization in diseases such as the neovascular (wet) form of age-related macular degeneration (AMD) or proliferative diabetic retinopathy. However, in the clinical context, patients with atrophic (dry) and wet AMD in the sam...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-15 | PXD066263 | Pride
Vegfr2 deletion Photoreceptor Lc-msms 
GenomicsEndothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs [Vegfr2_ecko_P21skin]
Endothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs [Vegfr2_ecko_P21skin]
PRJNA1508796 | ENA
GenomicsEndothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs [Vegfr2_siRNA_mLEC]
Endothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs [Vegfr2_siRNA_mLEC]
PRJNA1508818 | ENA
GenomicsEndothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs [Vegfr2_ecko_48h_skin]
Endothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs [Vegfr2_ecko_48h_skin]
PRJNA1508814 | ENA
GenomicsEndothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs [Vegfr2_lecko_P21skin]
Endothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs [Vegfr2_lecko_P21skin]
PRJNA1508821 | ENA
TranscriptomicsEndothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs [Vegfr2_siRNA_mLEC]
Vascular endothelial growth factor receptor-2 (VEGFR2) is a key target for regulating the endothelial cell lineage and angiogenesis. It is also expressed by lymphatic endothelial cells (LECs) while its participation in lymphangiogenesis remains inadequately characterized. We demonstrate in this stud...
ORGANISM(S): Mus musculus 
2026-08-11 | GSE342725 | GEO
TranscriptomicsEndothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs [Vegfr2_ecko_48h_skin]
Vascular endothelial growth factor receptor-2 (VEGFR2) is a key target for regulating the endothelial cell lineage and angiogenesis. It is also expressed by lymphatic endothelial cells (LECs) while its participation in lymphangiogenesis remains inadequately characterized. We demonstrate in this stud...
ORGANISM(S): Mus musculus 
2026-08-11 | GSE342728 | GEO
TranscriptomicsEndothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs [Vegfr2_lecko_P21skin]
Vascular endothelial growth factor receptor-2 (VEGFR2) is a key target for regulating the endothelial cell lineage and angiogenesis. It is also expressed by lymphatic endothelial cells (LECs) while its participation in lymphangiogenesis remains inadequately characterized. We demonstrate in this stud...
ORGANISM(S): Mus musculus 
2026-08-11 | GSE342723 | GEO
TranscriptomicsEndothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs [Vegfr2_ecko_P21skin]
Vascular endothelial growth factor receptor-2 (VEGFR2) is a key target for regulating the endothelial cell lineage and angiogenesis. It is also expressed by lymphatic endothelial cells (LECs) while its participation in lymphangiogenesis remains inadequately characterized. We demonstrate in this stud...
ORGANISM(S): Mus musculus 
2026-08-11 | GSE342716 | GEO
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