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MetabolomicsCirculating Metabolites in Progression to Islet Autoimmunity and Type 1 Diabetes

AIMS/HYPOTHESIS: Metabolic dysregulation may precede the onset of type 1 diabetes. However, these metabolic disturbances and their specific role in disease initiation remain poorly understood. In this study, we examined whether children who progress to type 1 diabetes have a cir...

2022-01-19 | MTBLS802 | MetaboLights
TranscriptomicsGenome-wide expression kinetics of children with Type 1 diabetes (T1D) -associated autoantibodies or progression towards clinical T1D, compared to healthy matched controls .
To unravel genes and molecular pathways involved in the pathogenesis of type 1 diabetes (T1D), we performed genome-wide gene expression profiling of prospective venous blood samples from children developing T1D-associated autoantibodies or progressing towards clinical diagnosis. 357 peripheral blood...
ORGANISM(S): Homo sapiens 
2014-02-20 | E-GEOD-43488 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression kinetics of children with T1D-associated autoantibodies compared to healthy matched controls I
To unravel genes and molecular pathways involved in the pathogenesis of type 1 diabetes (T1D), we performed genome-wide gene expression profiling of prospective venous blood samples from children developing T1D-associated autoantibodies or progressing towards clinical diagnosis. 63 peripheral blood ...
ORGANISM(S): Homo sapiens 
2014-02-20 | E-GEOD-30208 | biostudies-arrayexpress
ProteomicsSerum APOC1 levels are decreased in seroconverted children who progress to type 1 diabetes at a young age
Biomarkers are needed to accurately predict and monitor type 1 diabetes progression during the substantially heterogeneous presymptomatic period of the disease development. To address this concern, we studied temporal changes in the plasma and serum proteomes of < 5-year-old children with HLA-confer...
ORGANISM(S): Homo sapiens (Human) 
2023-09-26 | PXD033744 | Pride
Human Plasma Serum Type 1 diabetes Lc-ms/ms 
ProteomicsD12_iTRAQ
D12_1 and D12_2 are 8 plex iTRAQ analyses of depleted serum samples. The files are mgf files of collected SCX fractions that were analyzed with an Orbitrap Velos- Proxeon capillary LC combination. HCD fragmentation was used.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-06-24 | MSV000078759 | MassIVE
ProteomicsD14_LF
RAW files Case19T and Control19T represent D14 and Control-14 and are marked by their visit number. These are label free analyses of depleted serum samples conducted with an Orbitrap Velos- Proxeon capillary LC combination. CID fragmentation was used.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-06-24 | MSV000078760 | MassIVE
ProteomicsD6_iTRAQ
D6_1 and D6_2 are 8 plex iTRAQ analyses of depleted serum samples. The file represents mgf files of collected SCX fractions that were analyzed with an Orbitrap Velos- Proxeon capillary LC combination. HCD fragmentation was used
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-06-24 | MSV000078752 | MassIVE
ProteomicsD18_LF
Thermo RAW files Case18T and Control18T (Case and Cont) represent D18 and Control-18 and are marked by their visit number. These are label free analyses of depleted serum samples conducted with an Orbitrap Velos - Proxeon capillary LC combination. CID fragmentation was used. The samples were analyze...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-06-25 | MSV000078764 | MassIVE
ProteomicsD11_iTRAQ
D11_2 and D11_3 are 8 plex iTRAQ analyses of depleted serum samples. The files are mgf files of collected SCX fractions that were analyzed with an Orbitrap Velos- Proxeon capillary LC combination. HCD fragmentation was used.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-06-24 | MSV000078758 | MassIVE
ProteomicsData set D1
D1_1 and D1_2 are 8 plex iTRAQ analyses of depleted serum samples. The file represents mgf files of collected SCX fractions that were analyzed with an Orbitrap Velos- Proxeon capillary LC combination. HCD fragmentation was used
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-06-24 | MSV000078748 | MassIVE
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