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TranscriptomicsComparative genomic hybridization by array of mouse Brca1 and Brca2 mammary tumors
Comparison of mammary tumors from 35 Brca1F/F;p53F/F, 62 Brca2F/F;p53F/F and 33 p53F/F mice. For each mouse, tumor DNA was hybridized with its spleen DNA as a reference.
ORGANISM(S): Mus musculus 
2010-12-15 | E-NCMF-34 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization by array of mouse Brca1 and Brca2 mammary tumors
Comparison of mammary tumors from 35 Brca1F/F;p53F/F, 62 Brca2F/F;p53F/F and 33 p53F/F mice. For each mouse, tumor DNA was hybridized with its spleen DNA as a reference.
ORGANISM(S): Mus musculus 
2010-12-15 | E-NCMF-35 | biostudies-arrayexpress
GenomicsGlobal mapping of estrogen receptor and histone modifications in breast tumor samples uncovers distinct patterns for aromatase inhibitor resistance
ChIP-seq on primary breast cancer tumor samples for Era, H3K4me3, H3K27me3. Patients had a poor or good outcome after aromatase inhibitor treatment. Differential binding patterns between good and poor outcome patients were identified for each marker, predicting response to treatment comparing ER, H3...
ORGANISM(S): Homo sapiens 
2013-12-05 | E-GEOD-40867 | biostudies-arrayexpress
GenomicsEpigenetic changes due to histone eviction induced by anthracycline doxorubicin and aclarubicin
One major class of anti-cancer drugs targets topoisomerase II to induce DNA double-strand breaks and cell death of fast growing cells. Here, we compare three members of this class - the antracyclines doxorubicin and aclarubicin, and a chemically unrelated compound, etoposide. Aclarubicin does not i...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-33633 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse small cell lung cancer tumor samples
Expressionarray data for A functional role for tumor cell heterogeneity in a mouse model of Small Cell Lung Cancer
ORGANISM(S): Mus musculus 
2011-02-19 | E-NCMF-37 | biostudies-arrayexpress
TranscriptomicsDistinct effects of topoisomerase II inhibitors on tumor cell lines (part 1)
One major class of anti-cancer drugs targets topoisomerase II to induce DNA double-strand breaks and cell death of fast growing cells. Here, we compare three members of this class - the antracyclines doxorubicin and aclarubicin, and a chemically unrelated compound, etoposide. Aclarubicin does not i...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-33624 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization by array of mouse clonal cell lines derived from primary small cell lung cancer tumors
Clonal cell lines derived from primary murine Small Cell Lung Cancer tumors where analyzed by Comperative genomic hybridisation to identify common regions.
ORGANISM(S): Mus musculus 
2011-02-19 | E-NCMF-36 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouseWT vs CD137L-/- GC B cells
WT and CD137L-/- mice of 8-12 weeks old were immunized intra-peritoneally with 50 µg chicken gamma- globulin conjugated to 4-hydroxy-3-nitrophenylacetyl (NP-CG) in alum or infected intranasally with 25 hemagglutinin units of influenza virus strain A/NT/60/68 in 50 µl HBSS. Nine days after immuniza...
ORGANISM(S): Mus musculus 
2009-07-24 | E-NCMF-29 | biostudies-arrayexpress
GenomicsCo-regulated gene expression by estrogen receptor-a and liver receptor homolog-1 is a feature of the estrogen response in breast cancer cells
Our findings establish a key role for LRH-1 in the regulation of ERa target genes in breast cancer cells and identify a mechanism in which co-operative binding of LRH-1 and ERa at estrogen response elements controls the expression of estrogen responsive g Examination of ERα, with or without LRH-1 kn...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-49390 | biostudies-arrayexpress
GenomicsGenome-wide analysis of histone eviction by FAIRE-Seq
A major class of chemotherapeutics targets topoisomerase II for DNA double-strand breaks and cancer cell elimination. We compare four members of this class?the anthracyclines doxorubicin, daunorubicin and aclarubicin that does not induce DNA breaks?and a different compound, etoposide. We define a no...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-33632 | biostudies-arrayexpress
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