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GenomicsOncofusion protein AML1-ETO targets ERG factor binding sites in AML
ERG has been identified as an essential factor for the function and maintenance of adult hematopoietic stem cells and high ERG expression is a negative prognostic marker for treatment outcome in AML. The molecular function of ERG and its interplay with other factors is however largely unknown. Here ...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-23730 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD34+ derived neutrophil progenitors from umbilical cord blood, in response to Mek1 activation
analysis of differential gene expression in CD34+ derived neutrophil progenitors from umbilical cord blood, in response to Mek1 activation
ORGANISM(S): Homo sapiens 
2009-08-14 | E-TABM-754 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML
Mononuclear cells from AML patients (n=46) were sorted into CD34+ and CD34- subfractions and genome-wide expression analysis was performed using Illumina BeadChip Arrays (HT12 v3). Of 2 AML samples only the CD34+ fraction could be analyzed. AML CD34+ and CD34- gene expression was compared to a large...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-30029 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse quantitative trait loci (QTLs) in uantitative trait loci (QTLs) and brain to identify genes and loci that control hematopoietic stem cell (HSC) functioning
We have combined large-scale mRNA expression and gene mapping methods to identify genes and loci that control hematopoietic stem cell (HSC) functioning. mRNA expression levels were measured in purified HSC isolated from a panel of densely genotyped recombinant inbred mouse strains. Quantitative trai...
ORGANISM(S): Mus musculus 
2007-11-16 | E-GEOD-2031 | biostudies-arrayexpress
GenomicsNon-canonical PRC1.1 targets active genes independent of H3K27me3 and is essential for leukemogenesis
Polycomb proteins are classical regulators of stem cell self-renewal and cell lineage commitment and are frequently deregulated in cancer. Here we find that the non-canonical PRC1.1 complex, as identified by mass spectrometry-based proteomics, is critically important for human leukemic stem cells. D...
ORGANISM(S): Homo sapiens 
2015-11-24 | E-GEOD-54580 | biostudies-arrayexpress
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