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MetabolomicsDeletion of Gja1 in myocardium emerges ventricular arrhythmia and tachycardia by reprogramming proline metabolism
Connexin43 (Cx43) is the predominant connexin in working myocardium. Its expression decreases in various cardiovascular diseases, and accompanied by ventricular arrhythmias (VAs). However, molecular mechanisms underlying increased arrhythmogenesis remained unclear. Here we established iPSC-derived c...
2025-11-11 | MTBLS13302 | MetaboLights
ProteomicsResveratrol Suppresses Susceptibility of Ventricular Arrhythmia in Heart Failure Model
In a rabbit heart failure model, resveratrol treatment restored cardiac function, normalized calcium handling, and reduced ventricular arrhythmia by reversing ion channel downregulation, fibrosis, apoptosis, and inflammation. These findings highlight resveratrol’s cardioprotective potential as a the...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2026-01-12 | PXD069110 | Pride
Heart failure Calcium handling Ion channels Ventricular arrhythmia Optical mapping 
ProteomicsProteomics Study and Protein Biomarkers of Malignant Ventricular Arrhythmia in Acute Myocardial Infarction Patients
Acute myocardial infarction (AMI) is one of the leading causes of death. It is particularly important to predict malignant ventricular arrhythmia (MVA) timely and accurately in patients with AMI. This study aimed to explore biomarkers and to reveal possible mechanisms of MVA in AMI for clinical diag...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD041535 | Pride
Acute myocardial infarction  malignant ventricular arrhythmia  proteomics  data independent acquisition 
UnknownContemporary Management of Complex Ventricular Arrhythmias.
Not available
S-EPMC9194914 | biostudies-literature
ProteomicsTitin-dependent transient ventricular defects result in adult atrial arrhythmia and impaired contractility
Atrial fibrillation (AF), the most common arrhythmia, is occasionally associated with cardiac developmental defects, but causal relationships are poorly defined. Importantly, functional compensation for developmental defects may mask increased risk of arrhythmia in adults. Here, we deleted 9 amino a...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2024-08-09 | PXD038300 | Pride
Titin Cardiac potassium channel Atrial fibrillation Zebrafish 
TranscriptomicsMolecular Remodeling of Ion Channels in Human Atrial and Ventricular Myocytes Associated with Ischemic Cardiomyopathy
Ischemic cardiomyopathy (ICM) leads to congestive heart failure and can cause sudden cardiac death due to arrhythmia. Existing molecular knowledge base of ICM is rudimentary because of lack of specific attribution to cell type and function. This study was designed to investigate cell-specific molecu...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-17294 | biostudies-arrayexpress
GenomicsCardiac Arrhythmia Suppression Trial (CAST-BioLINCC)
Cardiac Arrhythmia Suppression Trial (CAST-BioLINCC)
PRJNA1454961 | ENA
GenomicsCardiac Arrhythmia Suppression Trial (CAST-BioLINCC)
Cardiac Arrhythmia Suppression Trial (CAST-BioLINCC)
PRJNA1454962 | ENA
GenomicsPhytosterol accumulation results in ventricular arrhythmia, impaired cardiac function and death
Phytosterol accumulation results in ventricular arrhythmia, impaired cardiac function and death
PRJNA723851 | ENA
UnknownA High Precision Machine Learning-Enabled System for Predicting Idiopathic Ventricular Arrhythmia Origins.
Not available
S-EPMC8962834 | biostudies-literature
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