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TranscriptomicsTranscription profiling of human multiple myeloma patients classified using the TC system to provide a molecular characterization of the TC groups
PURPOSE. The deregulation of CCND1, CCND2 and CCND3 genes represents a common event in multiple myeloma (MM). The recently proposed TC classification grouped MM patients into five classes on the basis of their cyclins D expression profiles and the presence of the main translocations involving the im...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-2912 | biostudies-arrayexpress
TranscriptomicsIntegrated genomics approach to detect allelic imbalances in multiple myeloma, SNP data
A SNP microarray and FISH-based procedure to detect allelic imbalances in multiple myeloma: an integrated genomics approach reveals a wide dosage effect on gene and microRNA expression Multiple myeloma (MM) is characterized by marked genomic instability. Beyond structural rearrangements, a relevant...
ORGANISM(S): Homo sapiens 
2009-05-16 | E-GEOD-16121 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human myeloma cell lines (23)
In order to investigate the patterns of genetic lesions in a panel of 23 Human Multiple Myeloma Cell Lines (HMCLs), we made a genomic integrative analysis involving FISH and both gene expression and genome-wide profiling approaches. The expression profiles of the genes targeted by the main IGH trans...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6205 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human multiple myelome samples reveals up-regulation of translational machinery and distinct genetic subgroups characterize hyperdiploidy
Karyotypic instability, including numerical and structural chromosomal aberrations, represents a distinct feature of multiple myeloma (MM). 40-50% of patients displayed hyperdiploidy, defined by recurrent trisomies of non-random chromosomes. To characterize hyperdiploid (H) and nonhyperdiploid (NH) ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6401 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human purified plasma cells (PCs) obtained from 90 newly diagnosed multiple myeloma (MM) reveals a distinct transcriptional and genetic features associated with chromosome 13 deletion in multiple myeloma
Background and objective: The chromosome 13 deletion (del(13)) represents one of the most frequent chromosomal alterations in multiple myeloma (MM). del(13) is associated with an unfavorable prognosis, although there is an increasing agreement that its prognostic relevance has to be related to the p...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6365 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human plasma cells from patients with monoclonal gammopathy of undetermined significance, multiple myeloma or plasma-cell leukaemia
This series of microarray experiments contains the gene expression profiles of purified plasma cells (PCs) obtained from 7 monoclonal gammopathy of undetermined significance (MGUS), 39 newly diagnosed multiple myeloma (MM) and 6 plasma-cell leukaemia (PCL) patients. PCs were purified from bone marro...
ORGANISM(S): Homo sapiens 
2007-08-30 | E-GEOD-2113 | biostudies-arrayexpress
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