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TranscriptomicsTranscription profiling of human umbilical cord blood and adult bone marrow CD34+CD33-CD38-Rho(lo)c-kit+ cells to identify candidate regulators of HSC self-renewal versus differentiation fate decisions
The global gene expression profiles of human umbilical cord blood and adult bone marrow CD34+CD33-CD38-Rho(lo)c-kit+ cells, enriched for hematopoietic stem/progenitor cells (HSC) with CD34+CD33-CD38-Rho(hi) cells, enriched in committed hematopoietic progenitor cells (HPC), were compared to identify ...
ORGANISM(S): Homo sapiens 
2007-10-30 | E-GEOD-2666 | biostudies-arrayexpress
TranscriptomicsIntrinsic differentiation potential of human postnatal MSC, Mab and MAPC reflected in their transcriptome
We have employed whole genome microarray expression profiling to identify genes that characterize different populations of human postnatal stem cells and reflect their potency MSC, Mab and MAPC cultures were established from at least three different donors and their transcriptome was assayed using t...
ORGANISM(S): Homo sapiens 
2011-07-12 | E-GEOD-23131 | biostudies-arrayexpress
TranscriptomicsTransduction of human fibroblasts with Zic3 combined with OCT4, SOX2 and KLF4 induces stable neural progenitor cell lines
Lineage specific transcription factors (TF) define and reinforce tissue specific cell types. For instance, stable endoderm progenitors were established from human ESC by constitutive expression of SOX7 or SOX17. We hypothesized that combinatorial expression of OCT4, SOX2 and KLF4M-BM- together with ...
ORGANISM(S): Homo sapiens 
2012-05-21 | E-GEOD-29770 | biostudies-arrayexpress
TranscriptomicsSuspension Differentiation of fibroblast-like pancreatic progenitors
The purpose of this microarray study was to analyze the initial changes in gene expression that occurred during the first 48 hours of a pancreatic progenitor differentiation scheme. The experiment compared both progenitors cultured normally in 10% SCM with nicotinamide as well as progenitors culture...
ORGANISM(S): Homo sapiens 
2014-07-15 | E-MTAB-2746 | biostudies-arrayexpress
TranscriptomicsRNA-seq of biopsies, crypts and organoids of inflamed and non-inflamed biopsies of ulcerative colitis patients
Patient-derived intestinal organoids provide an excellent tool to unravel mechanisms underlying ulcerative colitis (UC). Fresh biopsies, to isolate crypts and culture organoids, were obtained from both inflamed and non-inflamed regions from eight patients with active UC (Mayo endoscopic subscore ≥2)...
ORGANISM(S): Homo sapiens 
2020-10-08 | E-MTAB-7860 | biostudies-arrayexpress
TranscriptomicsHematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells
We used comparative transcriptome analysis to determine the relationship between rodent Multipotent Adult Progenitor Cells (MAPCs) and pluripotent embryonic stem cells (ESCs), or lineage restricted mesenchymal stem cells (MSCs) and neurospheres (NS). This comparison revealed a unique gene expression...
ORGANISM(S): Mus musculus 
2010-06-11 | E-GEOD-5947 | biostudies-arrayexpress
MetabolomicsGNPS Understanding the metabolic regulation of murine hematopoietic emergence
In vertebrates, lifelong supply of all the blood cell types in suitable numbers is maintained by the hematopoietic stem cells (HSCs). During development, these HSCs emerge in the aorta-gonad-mesonephros (AGM) from specialized vascular endothelium through a transdifferentiation process, called as end...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-06-02 | MSV000092085 | GNPS
TranscriptomicsTranscription profiling of mouse multipotent adult progenitor cells
We compare the transcriptome of embryonic stem cells (ESCs), adult stem cells with apparent greater differentiation potential such as multipotent adult progenitor cells (MAPCs), mesenchymal stem cells (MSCs) and neurospheres (NS). Mouse and rat MAPCs were used in this study and two different array p...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6933 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse multipotent adult progenitor cells (MAPCs), 2 different clones
We compare the transcriptome of two different clones of multipotent adult progenitor cells (MAPCs) using Affymetrix arrays. Experiment Overall Design: Three mRNA samples (biological replicates) per cell type taken at different passage number were compared. Two independently isolated MAPC clones were...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6291 | biostudies-arrayexpress
TranscriptomicsIn vitro differentiation of rat multipotent adult porgenitor cells to smooth muscle like cells
The aim of the study was to characterize the molecular mechanism involved in TGF-M-CM-^_ mediated smooth muscle formation in vitro. We employed rat bone marrow derived Oct4 expressing clones of multipotent adult progenitor cells (rMAPC). We subjected these cells to differentiation towards smooth mus...
ORGANISM(S): Rattus norvegicus 
2012-10-09 | E-GEOD-32990 | biostudies-arrayexpress
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