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UnknownPersonalized risk for clinical progression in cognitively normal subjects-the ABIDE project.

Background

Biomarkers such as cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) have predictive value for progression to dementia in patients with mild cognitive impairment (MCI). The pre-dementia stage takes far longer, and the interpretation of biomarker findings is particular...
S-EPMC6466790 | biostudies-literature
UnknownA neuroimaging approach to capture cognitive reserve: Application to Alzheimer's disease.
Cognitive reserve (CR) explains interindividual differences in the ability to maintain cognitive function in the presence of neuropathology. We developed a neuroimaging approach including a measure of brain atrophy and cognition to capture this construct. In a group of 511 Alzheimer's disease (AD) b...
S-EPMC6867139 | biostudies-literature
UnknownAssessment of white matter hyperintensity severity using multimodal magnetic resonance imaging.
White matter hyperintensities are radiological abnormalities reflecting cerebrovascular dysfunction detectable using MRI. White matter hyperintensities are often present in individuals at the later stages of the lifespan and in prodromal stages in the Alzheimer's disease spectrum. Tissue alterations...
S-EPMC10636521 | biostudies-literature
UnknownAmyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease.

Background

Major prevention trials for Alzheimer's disease (AD) are now focusing on multidomain lifestyle interventions. However, the exact combination of behavioral factors related to AD pathology remains unclear. In 2 cohorts of cognitively unimpaired individuals at risk of AD, we examined...
S-EPMC7415608 | biostudies-literature
UnknownAssociations between neuromelanin depletion and cortical rhythmic activity in Parkinson's disease.
Parkinson's disease (PD) is marked by the death of neuromelanin-rich dopaminergic and noradrenergic cells in the substantia nigra (SN) and the locus coeruleus (LC), respectively, resulting in motor and cognitive impairments. Although SN dopamine dysfunction has clear neurophysiological effects, the ...
S-EPMC11884654 | biostudies-literature
UnknownInsulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains.
Insulin, insulin-like growth factors (IGF) and their receptors are highly expressed in the adult hippocampus. Thus, disturbances in the insulin-IGF signalling pathway may account for the selective vulnerability of the hippocampus to nascent Alzheimer's disease (AD) pathology. In the present study, w...
S-EPMC11068109 | biostudies-literature
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