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TranscriptomicsTranscription profiling of gentamicin susceptible and resistant strains of rat treated with gentamicin
Comparison of Gentamicin 4 drug-treated individuals vs. 4 vehicle-treated, pooled individuals composed of 2 forward-labeled (Cy5: drug-treated individual, Cy3: vehicle-treated pool) and 2 reverse-labeled (Cy5: vehicle-treated pool, Cy3: drug-treated individual) slides. These comparisons were done a...
ORGANISM(S): Rattus norvegicus 
2006-04-01 | E-MEXP-544 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of four strains of rat treated with acetaminophen
Comparison of acetaminophen: 4 drug-treated individuals vs. 4 vehicle-treated, pooled individuals composed of 2 forward-labeled (Cy5: drug-treated individual, Cy3: vehicle-treated pool) and 2 reverse-labeled (Cy5: vehicle-treated pool, Cy3: drug-treated individual) slides. These comparisons were don...
ORGANISM(S): Rattus norvegicus 
2006-08-17 | E-TABM-131 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of four strains of rat treated with tacrine
Comparison of tacrine 4 drug-treated individuals vs. 4 vehicle-treated, pooled individuals composed of 2 forward-labeled (Cy5: drug-treated individual, Cy3: vehicle-treated pool) and 2 reverse-labeled (Cy5: vehicle-treated pool, Cy3: drug-treated individual) slides. These comparisons were done acros...
ORGANISM(S): Rattus norvegicus 
2006-08-14 | E-TABM-129 | biostudies-arrayexpress
MetabolomicsCell overgrowth potentiates osmotic and replication stresses to promote p38/p53/p21-dependent senescence
Abnormal increases in cell size are associated with senescence and cell cycle exit. The mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain unknown. We address this question using CDK4/6 inhibitors, which arrest cells in G0/G1 and are licensed to treat advanced HR+/HER...
2025-10-24 | MTBLS8698 | MetaboLights
MetabolomicsCDK4/6 inhibitor-mediated cell overgrowth triggers an osmotic stress response and chronic p38MAPK activation to promote long-term cell cycle arrest

Cell size and the cell cycle are intrinsically coupled and abnormal increases in cell size are associated with senescence and permanent cell cycle arrest. The mechanism by which overgrowth primes cells to withdraw from the cell cycle remains unknown. We investigate this here using CDK4/6 inhibito...

2025-10-24 | MTBLS5868 | MetaboLights
TranscriptomicsmicroRNA expression in rat lung receiving chemopreventive agents and attenuation of cigarette smoke-induced alterations
We previously showed that exposure of rats to environmental cigarette smoke (ECS) causes extensive downregulation of microRNA expression in the lung, resulting in overexpression of multiple genes and proteins. In the present study, we evaluated by microarray the expression of 484 microRNAs in the l...
ORGANISM(S): Rattus norvegicus 
2010-05-16 | E-GEOD-19540 | biostudies-arrayexpress
TranscriptomicsShear Stress and NOTCH1 Regulate Calcification Related Genes in Human Aortic Valve Endothelium
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-05-16 | E-GEOD-47160 | biostudies-arrayexpress
UnknownRole of Educational Exposure in the Association Between Myopia and Birth Order.
Not available
S-EPMC4681114 | biostudies-literature
UnknownDifferentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort.
Not available
S-EPMC11408082 | biostudies-literature
UnknownDevelopment of a Clinical Prediction Model for Anastomotic Leakage in Colorectal Surgery.
Not available
S-EPMC12538359 | biostudies-literature
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