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ProteomicsProteomic and phosphoproteomic profiling of mouse embryonic fibroblasts
Fibroblasts are the most common cell type in stroma and function in the support and repair of most tissues. Mouse embryonic fibroblasts (MEFs) are amenable to isolation and rapid growth in culture. To facilitate their use as a research tool, we have performed a comprehensive proteomic and phosphopro...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-20 | PXD043244 | Pride
Phosphoproteomics Proteomics Fibroblasts 
ProteomicsProteomic and phosphoproteomic profiling of D816V- and V560G-mutant KIT cells
The CD117 mast/stem cell growth factor receptor tyrosine kinase (KIT) is critical for haematopoiesis, melanogenesis, and stem cell maintenance. KIT is commonly activated by mutation in cancers including acute myeloid leukaemia, melanoma, and gastrointestinal stromal tumours (GISTs). The kinase and t...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-19 | PXD043783 | Pride
Proteomics Phosphoproteomics Kit Aml 
ProteomicsSynergistic targeting of DNA-PK and KIT signaling pathways in KIT mutant acute myeloid leukemia
Acute Myeloid Leukemia (AML) is the most common and aggressive form of acute leukemia, with a 5-year survival rate of just 24%. Over a third of all AML patients harbor activating mutations in kinases, such as the receptor tyrosine kinases FLT3 and KIT. FLT3 and KIT mutations are associated with poor...
ORGANISM(S): Mus Musculus 
2023-01-26 | PXD030214 | panorama
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