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TranscriptomicsTranscriptional response to hypoxia of normal and rheumatoid arthritis synovial fibroblasts
Inflammatory tissues are characterized by low oxigen concentrations (hypoxia). These conditions are very different from that usually present in tissue cultures where transcriptomic profiles of human fibroblasts from inflammatory tissues have been previously analysed. The aim of this study was to cha...
ORGANISM(S): Homo sapiens 
2010-12-10 | E-GEOD-21959 | biostudies-arrayexpress
TranscriptomicsComprehensive transcriptome analysis of synovium and peripheral blood reveals major disease heterogeneity early in the RA disease process prior to therapeutic intervention
We report the first comparative analysis between histology, RNA-seq of synovium and matched peripheral blood, and clinico-radiological parameters in early rheumatoid arthritis (RA). Using a novel modular approach, we describe underlying pathways associated with three pre-dominant RA pathotypes. Myel...
ORGANISM(S): Homo sapiens 
2020-04-09 | E-MTAB-6141 | biostudies-arrayexpress
TranscriptomicsIdentification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation
Discrimination of rheumatoid arthritis (RA) patients from patients with other inflammatory/degenerative joint diseases or healthy individuals purely on the basis of genes differentially expressed in high-throughput data has proven very difficult. Thus, the present study sought to achieve such discri...
ORGANISM(S): Homo sapiens 
2014-02-21 | E-GEOD-55235 | biostudies-arrayexpress
ProteomicsAnti-carbamylated fibrinogen antibodies, that might be related to a particular rheumatoid phenotype, include a subset recognizing in vivo epitopes of its γ chain whose one of them is not cross reactive with ACPA
To identify the targets recognized by anti-carbamylated protein (anti-CarP) antibodies in patients with early Rheumatoid Arthritis (RA), to study the cross-reactivity between anti-CarP and anti-citrullinated protein antibodies (ACPA) and to evaluate their prognostic value. 331 patients (184 RA and 1...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD028121 | Pride
Very early rheumatoid arthritis Acpa Anti-carbamylated protein/peptide antibodies (anti-carp) Fibrinogen Prognosis 
UnknownVery early MRI responses to therapy as a predictor of later radiographic progression in early rheumatoid arthritis.
Not available
S-EPMC6805378 | biostudies-literature
UnknownA prospective, single-centre, randomised study evaluating the clinical, imaging and immunological depth of remission achieved by very early versus delayed Etanercept in patients with Rheumatoid Arthritis (VEDERA).
Not available
S-EPMC4743173 | biostudies-literature
UnknownExpression of chemokines CXCL4 and CXCL7 by synovial macrophages defines an early stage of rheumatoid arthritis.
Not available
S-EPMC4819606 | biostudies-literature
UnknownACPA fine-specificity profiles in early rheumatoid arthritis patients do not correlate with clinical features at baseline or with disease progression.
Not available
S-EPMC3978944 | biostudies-literature
UnknownBaseline Objective Inflammation by Magnetic Resonance Imaging as a Predictor of Therapeutic Benefit in Early Rheumatoid Arthritis With Poor Prognosis.
Not available
S-EPMC7383909 | biostudies-literature
UnknownIs there subclinical synovitis in early psoriatic arthritis? A clinical comparison with gray-scale and power Doppler ultrasound.
Not available
S-EPMC4282111 | biostudies-literature
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