Transcriptional response to hypoxia of normal and rheumatoid arthritis synovial fibroblasts

ABSTRACT: Inflammatory tissues are characterized by low oxigen concentrations (hypoxia). These conditions are very different from that usually present in tissue cultures where transcriptomic profiles of human fibroblasts from inflammatory tissues have been previously analysed. The aim of this study was to characterize the changes on gene expression induced by hypoxia in human synovial fibroblasts. We used microarray expression profiling in paired normoxic and hypoxic cultures of healthy and rheumatoid arthritis (RA) synovial fibroblasts (HSF and RASF). Hypoxia induces significant changes on the expression of large groups of genes in both HSF and RASF. The hypoxic and normoxic profiles are also different between both groups. These data demonstrate that hypoxia induces significant changes on gene expr

ORGANISM(S): Homo sapiens

SUBMITTER: Manuel Del Rey 

PROVIDER: E-GEOD-21959 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress