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TranscriptomicsmRNA Sequencing Reveals Altered Synaptic Vesicular Transport in Post-Mortem Cerebellum
Schizophrenia (SCZ) is a common, disabling mental illness with high heritability but complex, poorly understood genetic etiology. As the first phase of a genomic convergence analysis of SCZ, we generated 16.7 billion nucleotides of short read, shotgun sequences of cDNA from post-mortem cerebellar c...
ORGANISM(S): Homo sapiens 
2009-08-29 | E-GEOD-12297 | biostudies-arrayexpress
ProteomicsLztr1 loss leads to Noonan syndrome-like vascular defects by dysregulating vesicular trafficking
Mutations in LZTR1, an adaptor for cullin 3 (CUL3) ubiquitin ligase complex, are associated with glioma, hepatocarcinoma, paediatric cancers, Schwannomatosis, and Noonan syndrome (NS). NS is a poorly understood and complex disease. The variety of NS phenotypes makes it challenging to elucidate the m...
ORGANISM(S): Homo sapiens (Human) 
2020-10-14 | PXD011926 | Pride
Hela cells Vegf Noonan syndrome Lztr1 Vesicular trafficking Ubiquitin Chmp1b 
TranscriptomicsTranscriptome modulation of ventricles, cardiomyocytes and cardiac fibroblasts during postnatal mouse development
During development the fetal heart undergoes a rapid and dramatic transition to adult function through transcriptional and post-transcriptional mechanisms, including alternative splicing (AS). We performed deep RNA-sequencing for high-resolution analysis of transcriptome changes during postnatal mou...
ORGANISM(S): Mus musculus 
2014-04-16 | E-GEOD-49906 | biostudies-arrayexpress
GenomicsKATNAL2 mutation cause hydrocephalus by impairing vesicular trafficking and ependymal cell polarity in ASD
KATNAL2 mutation cause hydrocephalus by impairing vesicular trafficking and ependymal cell polarity in ASD
PRJNA1168536 | ENA
TranscriptomicsThe importance of vesicular trafficking pathways in genome stability of diploid Saccharomyces cerevisiae cells
The ability to survive stress conditions is important for every living cell. Some stresses can affect not only current cell well-being, but may have far-reaching consequences. Uncurbed oxidative stress can cause DNA damage and the decrease in cell survival and/or increase in mutation rate. Some subs...
ORGANISM(S): Saccharomyces cerevisiae 
2015-03-16 | GSE59193 | GEO
TranscriptomicsKATNAL2 mutation cause hydrocephalus by impairing vesicular trafficking and ependymal cell polarity in ASD
Autism spectrum disorders (ASD) are characterized by intricate neurodevelopmental abnormalities, yet the molecular underpinnings remain elusive for many high-risk genes, including KATNAL2. Here, we identify KATNAL2 as a key regulator of the intracellular vesicular system in the ependymal epithelium,...
ORGANISM(S): Mus musculus 
2025-05-01 | GSE278728 | GEO
UnknownPrimary cilium suppression by SREBP1c involves distortion of vesicular trafficking by PLA2G3.
Not available
S-EPMC4462948 | biostudies-literature
UnknownVesicular trafficking permits evasion of cGAS/STING surveillance during initial human papillomavirus infection.
Not available
S-EPMC7728285 | biostudies-literature
TranscriptomicsTranscription profiling of peripheral blood or primary finroblast cultures from choroideremia patients to determine if loss-of-function mutations in REP-1 affect intracellular vesicle transport in fibroblasts and monocytes of CHM patients
Choroideremia (CHM) is a progressive X-linked retinopathy caused by mutations in the CHM gene, which encodes Rab escort protein-1 (REP-1), an escort protein involved in the prenylation of Rabs. Under-prenylation of certain Rabs, as a result of loss of function mutations in REP-1, could affect vesicu...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-17549 | biostudies-arrayexpress
UnknownOverexpressing OsPIN2 enhances aluminium internalization by elevating vesicular trafficking in rice root apex.
Not available
S-EPMC4623688 | biostudies-literature
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