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TranscriptomicsTranscription profiling of four human prostate cancer cell lines and seven prostate cancer xenografts
Gene expression profiling of four prostate cancer cell lines and seven prostate cancer xenografts. The experiment was done to see which genes were over- or underexpressed in the samples. The results were combined with aCGH results of the same samples (experiment prostate cancer CGH) to see, whether ...
ORGANISM(S): Homo sapiens 
2005-12-30 | E-MEXP-336 | biostudies-arrayexpress
UnknownTargeted androgen pathway suppression in localized prostate cancer: a pilot study.
Not available
S-EPMC3887479 | biostudies-literature
TranscriptomicsMolecular alterations in prostate carcinomas that associate with in vivo exposure to chemotherapy
Patients with high-risk localized prostate cancer (tumor-node-metastasis ≥ T2b or prostate-specific antigen ≥ 15 ng/mL or Gleason glade ≥ 4+3) were enrolled into a phase II clinical trial of neoadjuvant chemotherapy with docetaxel and mitoxantrone followed by prostatectomy. Pretreatment prostate tis...
ORGANISM(S): Homo sapiens 
2012-08-29 | E-GEOD-40434 | biostudies-arrayexpress
TranscriptomicsCellular adhesion promotes prostate cancer cells escape from dormancy
Dissemination of prostate cancer (PCa) cells to the bone marrow is an early event in the disease process. In some patients, following initial treatment, disseminated tumor cells (DTC) proliferate to form active metastases after a prolonged period of undetectable disease known as tumor dormancy. Iden...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-64262 | biostudies-arrayexpress
TranscriptomicsProstate CancerM-bM-^@M-^SAssociated Gene Expression Alterations Determined from Needle Biopsies
To accurately identify gene expression alterations that differentiate neoplastic from normal prostate epithelium using an approach that avoids contamination by unwanted cellular components and is not compromised by acute gene expression changes associated with tumor devascularization and resulting i...
ORGANISM(S): Homo sapiens 
2012-08-24 | E-GEOD-40373 | biostudies-arrayexpress
TranscriptomicsInhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer
We analyzed transcriptional changes in 4 prostate cancer cell lines following treatment with the BET inhibitor I-BET762 using Affymetrix Human Genome U133 Plus 2.0 Arrays. Four prostate cancer cell lines (NCI-H660, VCaP, LNCaP, PC-3) were treated with DMSO (control) or I-BET762 at 0.5uM or 10uM con...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-GEOD-56352 | biostudies-arrayexpress
TranscriptomicsComparative analyses of chromosome alterations in metastases in castration-resistant prostate cancer patients
Androgen deprivation is the mainstay of therapy for progressive prostate cancer. Despite initial and dramatic tumor inhibition, most men eventually fail therapy and die of metastatic castration-resistant (CR) disease. Here, we characterize the profound degree of genomic alteration found in CR tumors...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-18259 | biostudies-arrayexpress
TranscriptomicsSRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer
The neuroendocrine (NE) phenotype is associated with the development of metastatic castration-resistant prostate cancer (CRPC). Our objective was to characterize the molecular features of the NE phenotype in CRPC. Expression of chromogranin A (CHGA), synaptophysin (SYP), androgen receptor (AR), and ...
ORGANISM(S): Homo sapiens 
2015-06-24 | E-GEOD-66187 | biostudies-arrayexpress
TranscriptomicsA Characterization of Osteoblastic and Osteolytic Proteins in Prostate Cancer Bone Metastases
Our goal was to determine whether previously identified and novel proteins are associated with the osteoblastic or osteolytic response in clinical specimens of PCa bone metastases. Custom Agilent 44K whole human genome expression oligonucleotide microarrays were used to profile 14 PCa metastases fro...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-41619 | biostudies-arrayexpress
TranscriptomicsMolecular Profiling of Metastatic Prostate Carcinoma Reveals Substantial Inter-individual and Limited Intra-individual Diversity: Implications for Precision Oncology
Prostate cancers exhibit a spectrum of molecular aberrations of which a substantial subset are amenable to targeted therapeutics. To determine the diversity of somatic alterations present in metastasis within and between individuals we characterized the genomic landscapes of 176 tumors acquired from...
ORGANISM(S): Homo sapiens 
2015-12-18 | E-GEOD-74685 | biostudies-arrayexpress
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