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ProteomicsDysregulation of protein homeostasis by mutant UBA1 in VEXAS syndrome
VEXAS is a hematopoietic disorder characterized by hyperinflammation,high mortality, and mutations at methionine 41 (M41) in the E1 ubiquitin enzyme, UBA1. Here, we developed ahuman model of VEXAS by engineering the male THP1 cell line to express the UBA1-M41V mutation. We found that UBA1-M41V cells...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD063067 | Pride
Human Vexas 
ProteomicsDysregulation of protein homeostasis by mutant UBA1 in VEXAS syndrome
VEXAS is a hematopoietic disorder characterized by hyperinflammation,high mortality, and mutations at methionine 41 (M41) in the E1 ubiquitin enzyme, UBA1. Here, we developed ahuman model of VEXAS by engineering the male THP1 cell line to express the UBA1-M41V mutation. We found that UBA1-M41V cells...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD063068 | Pride
Vexas Uba1 
GenomicsTranscriptomic profiling of VEXAS syndrome patients
Transcriptomic profiling of VEXAS syndrome patients
PRJNA672843 | ENA
GenomicsUBA1 dependent inflammation in VEXAS is mediated by cGAS-STING
UBA1 dependent inflammation in VEXAS is mediated by cGAS-STING
PRJNA1255153 | ENA
GenomicsSingle-cell profiling of hematopoietic cells in VEXAS syndrome
Single-cell profiling of hematopoietic cells in VEXAS syndrome
PRJNA803179 | ENA
GenomicsSingle-cell RNA sequencing of blood cells from patients with VEXAS syndrome.
Single-cell RNA sequencing of blood cells from patients with VEXAS syndrome.
PRJNA1047528 | ENA
UnknownThrombosis in VEXAS syndrome.
Not available
S-EPMC8612112 | biostudies-literature
UnknownJoint involvement in VEXAS and non-VEXAS clonal haematopoiesis: two clusters from a multicentre regional cohort.
Not available
S-EPMC12574337 | biostudies-literature
TranscriptomicsUBA1 dependent inflammation in VEXAS is mediated by cGAS-STING
VEXAS (vacuoles, E1, X-linked, autoinflammatory, somatic) is a genetic disease caused by somatic mutations in UBA1, resulting in severe, systemic autoinflammation and hematologic manifestations. UBA1 encodes the E1 ubiquitin-activating enzyme, which is essential for initiating the majority of ubiqui...
ORGANISM(S): Homo sapiens 
2026-09-22 | GSE295539 | GEO
GenomicsVEXAS syndrome is characterized by blood and tissues inflammasome pathway activation and monocyte dysregulation
VEXAS syndrome is characterized by blood and tissues inflammasome pathway activation and monocyte dysregulation
PRJNA894197 | ENA
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