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TranscriptomicsTranscription profiling of lymph node T cells isolated from Ezh2fl/fl or Ezh2 deficient mice to study the role of ezh2 on actin polymerization and cell signaling
Lymph node T cells isolated from Ezh2fl/fl or Ezh2 deficient mice
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-1566 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary breast tumors and MDA-MB-231 subpopulations
Subpopulations of MDA-MB-231 that exhibit different metastatic tropisms when injected into immuno-deficient mice. Also, a cohort of primary breast cancers surgically resected at the Memorial Sloan-Kettering Cancer Center (MSKCC).
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2603 | biostudies-arrayexpress
TranscriptomicsMolecular and functional characterization of FD-iPSC derived neural crest precursor cells
Global gene expression analysis of FD-iPSC and deribved neural crest cells Here we report the derivation of patient specific Familial Dysautonomia-iPSCs and their directed differentiation into multiple cell types capable of modeling the tissue specific splicing defect in vitro. Undifferentiated hES...
ORGANISM(S): Homo sapiens 
2009-08-31 | E-GEOD-17043 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Nbs1a??B/a??B Chk2-/- and Mre11ATLD1/ATLD1 Chk2-/- animals reveals Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
The Mre11 complex (Mre11, Rad50, and Nbs1) and Chk2 have been implicated in the DNA damage response, an inducible process required for the suppression of malignancy. The Mre11 complex is predominantly required for repair and checkpoint activation in S phase, while Chk2 governs apoptosis. We examin...
ORGANISM(S): Homo sapiens 
2008-06-20 | E-GEOD-11436 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse spermatogonia in wild type vs Zpf145 knockout backgrounds reveals Plzf is essential for maintenance of spermatogonial stem cells.
Expression analysis of spermatogonia in a wild type or Zfp145 knock out background
ORGANISM(S): Mus musculus 
2007-09-29 | E-GEOD-1399 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Human embryonic stem cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage
All data are derived from the same batch of human ES cells (line H9, WA-09). With the exception of the â??UDâ?? file all files represent neural cell types derived from the undifferentiated hESCs. Following mechanical isolation, rosettes were maintained for various passages in the presence of defined...
ORGANISM(S): Homo sapiens 
2008-04-07 | E-GEOD-9921 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic fibroblasts deleted for G9a reconstituted with empty vector (delta), wild type FLAG-G9a (WT), FLAG-G9a K165A (K165A) or FLAG-G9a H1093K catalytic mutant reveasl methylation of hMTase G9a on a histone-like site regulates protein complex assembly
Gene expression in eukaryotes is tightly linked to the methylation state of specific lysine residues within the N-terminal region of the core histone proteins. While the mechanisms connecting histone lysine methylation to effector protein recruitment and control of gene activity are increasingly wel...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-8011 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD34 cells isolated from cord blood or peripheral blood transduced with AML1-ETO or empty vector (MIGR1)
Human CD34 cells isolated from cord blood or peripheral blood transduced with AML1-ETO or empty vector (MIGR1).
ORGANISM(S): Homo sapiens 
2007-08-30 | E-GEOD-2049 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild type embryonic stem cells after blastocytst injection revealglobal corrections in MDX mice.
Duchenne muscular dystrophy (DMD) is an incurable neuromuscular degenerative disease, caused by a mutation in the dystrophin gene. Mdx mice recapitulate DMD features. Here we show that injection of wild-type (WT) embryonic stem cells (ESCs) into mdx blastocysts produces mice with improved pathology...
ORGANISM(S): Mus musculus 
2008-10-25 | E-GEOD-12580 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lung tumor tissue from TI-K (CCSP-rtTA;TRE-KrasV12), TI-KM (CCSP-rtTA; TRE-KrasV12; TRE-Mad2), recurrence (TI-KM) or normal lung tissue (CCSP-rtTA) reveals Mad2-induced chromosome instability leads to lung tumor relapse after oncogene withdrawal
Inhibition of an initiating oncogene often leads to extensive tumor cell death, a phenomenon known as oncogene addiction. This has led to the search for compounds that specifically target and inhibit oncogenes as anti-cancer agents. Whether chromosomal instability (CIN) generated as a result of dere...
ORGANISM(S): Mus musculus 
2010-01-22 | E-GEOD-19753 | biostudies-arrayexpress
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