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MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
TranscriptomicsMicroRNA sequencing of human serum exosomes from women with different age and hormonal status
This study investigated differences in serum exosome microRNA-cargo, obtained from healthy postmenopausal monozygotic twins (n=10 pairs), from which the other sister was using estrogen-based hormone replacement therapy (HRT) and the other was not under treatment. In addition, premenopausal women (n=...
ORGANISM(S): Homo sapiens 
2017-02-14 | E-MTAB-5245 | biostudies-arrayexpress
GenomicsGenome-wide identification of Ikaros binding sites in pre-B cells
Ikaros DNA binding proteins are important regulators of haematopoiesis and genetic deletion of Ikaros results in severe developmental disturbances, including delayed thymocyte differentiation and an early and complete block in B cell development. Although Ikaros ChIP-seq data are available for mouse...
ORGANISM(S): Mus musculus 
2013-01-15 | E-GEOD-38169 | biostudies-arrayexpress
GenomicsGenome-wide identification of Ikaros binding sites in primary pre-B cells
Ikaros DNA binding proteins are important regulators of haematopoiesis and genetic deletion of Ikaros results in severe developmental disturbances, including delayed thymocyte differentiation and an early and complete block in B cell development. Although Ikaros ChIP-seq data are available for mouse...
ORGANISM(S): Mus musculus 
2013-01-15 | E-GEOD-42462 | biostudies-arrayexpress
UnknownOncological treatments have limited effects on the fertility prognosis in testicular cancer: A systematic review and meta-analysis.
Not available
S-EPMC12006886 | biostudies-literature
TranscriptomicsSingle-cell RNA sequencing data of zebrafish lymphatic and venous endothelial cells at different developmental stages (36 hpf, 48 hpf, 120 hpf (5 dpf) and 168 hpf (7 dpf))
This dataset contains single-cell RNA sequencing (scRNA-seq) profiles of zebrafish venous and lymphatic endothelial cells across development. Endothelial cells were isolated by FACS from transgenic zebrafish embryos and larvae at 36 hpf, 48 hpf, 5 dpf (120 hpf), and 7 dpf (168 hpf) using endothelial...
ORGANISM(S): Danio rerio 
2026-09-28 | E-MTAB-16797 | biostudies-arrayexpress
GenomicsA Genome-Wide Association Study of Peripheral Arterial Disease

The Electronic Medical Record Phenotypes and Community-engaged Genomic Association Study aims to identify genetic variants mediating susceptibility to peripheral arterial disease (PAD). The study leverages a biorepository of blood samples of 1688 PAD cases and 1649 controls, and the electronic ...

phs000203.v1.p1 | EGA
UnknownIntratumoral immunosuppression profiles in 11q-deleted neuroblastomas provide new potential therapeutic targets.
Not available
S-EPMC7858123 | biostudies-literature
GenomicsMETABRIC miRNA landscape
MicroRNAs (miRNAs) are key players in cancer pathogenesis1. They display differential expression across breast cancer subtypes, and play oncogenic and tumor-suppressive roles2-6. A systematic study of the global miRNA landscape in breast cancer and the factors shaping it has not been undertaken. Her...
EGAS00000000122 | EGA
GenomicsMETABRIC
The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We present an integrated analysis of copy number and gene expression in a discovery and validation set of 997 and 995 primary brea...
EGAS00000000083 | EGA
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