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TranscriptomicsComparative Hi-C reveals that CTCF underlies evolution of chromosomal domain architecture.
Topological domains are key architectural building blocks of chromosomes in complex genomes. Their functional importance and evolutionary dynamics are however not well defined. Here we performed comparative Hi-C in liver cells from four mammalian species, and characterized the conservation and dive...
ORGANISM(S): Canis lupus familiaris 
2015-02-26 | E-GEOD-65126 | biostudies-arrayexpress
TranscriptomicsCohesin is a key determinant of interphase chromosome domain architecture (RNA-seq)
To ensure proper gene regulation within constrained nuclear space, chromosomes facilitate access to transcribed regions, while compactly packaging all other information. Recent studies revealed that chromosomes are organized into megabase-scale domains that demarcate active and inactive genetic elem...
ORGANISM(S): Mus musculus 
2013-12-11 | E-GEOD-48965 | biostudies-arrayexpress
GenomicsCohesin is a key determinant of interphase chromosome domain architecture (ChIP-seq)
To ensure proper gene regulation within constrained nuclear space, chromosomes facilitate access to transcribed regions, while compactly packaging all other information. Recent studies revealed that chromosomes are organized into megabase-scale domains that demarcate active and inactive genetic elem...
ORGANISM(S): Mus musculus 
2013-12-11 | E-GEOD-48938 | biostudies-arrayexpress
TranscriptomicsCohesin is a key determinant of interphase chromosome domain architecture (HiC)
To ensure proper gene regulation within constrained nuclear space, chromosomes facilitate access to transcribed regions, while compactly packaging all other information. Recent studies revealed that chromosomes are organized into megabase-scale domains that demarcate active and inactive genetic elem...
ORGANISM(S): Mus musculus 
2013-12-11 | E-GEOD-49017 | biostudies-arrayexpress
ProteomicsUuskula_P112_VS2_TOP2B_BioID_15JUN2015
This submission contains the mass spectrometry files for the manuscript by Uuskula-Reimand et al. that investigates the interactome of TOP2B using BioID and its genomic binding profile. This submission contains 18 IDA files for the following baits: empty 3XFLAG control, GFP-BirA-FLAG control, NLS-Bi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-07-10 | MSV000079188 | MassIVE
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