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Transcriptomicsalternative promoter array HeLa HIF1 ChIP-chip
DNA binding profiling of endogenous HIF1A on proximal promoters in human HeLa cells exposed to 1% oxygen (hypoxia), using normoxic cells (21% oxygen) as reference.

Biological background: The Hypoxia Inducible Factor Family of transcription factors is proposed as the main orchestrator of the c...
ORGANISM(S): Homo sapiens 
2012-05-20 | E-MEXP-3499 | biostudies-arrayexpress
Genomics20Mammals
Definition of functional regulatory regions in the vast non-coding fractions of mammalian genomes remains a daunting challenge that underscores our limited understanding of mammalian gene regulation. Genome sequencing of many mammals has recently been exp
ORGANISM(S): Heterocephalus glaber 
2015-01-29 | E-MTAB-2633 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of gene expression divergence in mammalian liver
The connection between evolution of regulatory elements and downstream gene expression is incompletely understood in mammals. We carried out a large-scale comparison of matched ChIP-seq and RNA-seq experiments across twenty species of mammals, using liver as a model somatic tissue. Herein we report ...
ORGANISM(S): Lemur catta 
2017-10-11 | E-MTAB-4550 | biostudies-arrayexpress
MetabolomicsExtreme genome diversity and cryptic speciation in a harmful algal bloom forming eukaryote

Harmful algal blooms (HABs) of the toxic haptophyte Prymnesium parvum are a recurrent problem in many inland and estuarine waters around the world. Strains of P. parvum vary in the toxins they produce and in other physiological traits associated with HABs, but the genetic basis ...

2023-04-26 | MTBLS5893 | MetaboLights
GenomicsMitochondrial heteroplasmy in vertebrates using ChIP-sequencing data
Mitochondrial heteroplasmy, the presence of more than one mtDNA variant in a cell or individual is not as uncommon as previously thought. It is mostly due to the high mutation rate of the mtDNA and limited repair mechanisms present in the mitochondrion. The phenomenon has been studied mostly in huma...
ORGANISM(S): Heterocephalus glaber 
2016-05-13 | E-MTAB-3933 | biostudies-arrayexpress
TranscriptomicsRNA-seq of liver tissue and liver cancer cell lines
This dataset has been designed to test whether codons in mRNAs and anticodons in tRNAs vary in order to maximize translation in specific cellular conditions in mammals. Prokaryotes and simple unicellular eukaryotes optimize their translational rates by adjusting the codons in the protein-coding tran...
ORGANISM(S): human 
2016-04-18 | E-MTAB-4052 | biostudies-arrayexpress
TranscriptomicsExpression data from Arabidopsis thaliana WT (Ler), ebs and shl-2 mutants grown in short day conditions
We performed a tranascriptomic analysis of Ler, ebs and shl-2 plants in order to reveal targets whose transcription is regulated by EBS and SHL. The analysis was performed in WT plants (Ler), as well as mutants plants in which the expression of EBS and SHL was previously shown to be null, namely ebs...
ORGANISM(S): Arabidopsis thaliana 
2014-10-14 | E-GEOD-33270 | biostudies-arrayexpress
UnknownIdentification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains.
Not available
S-EPMC2267344 | biostudies-literature
TranscriptomicsIntegrated metabolomics, transcriptomics and proteomics identifies metabolic pathways affected by Anaplasma phagocytophilum infection in tick cells
Anaplasma phagocytophilum is an emerging zoonotic pathogen that causes human granulocytic anaplasmosis. These intracellular bacteria establish infection by affecting cell function in both the vertebrate host and the tick vector, Ixodes scapularis. Previous studies have characterized the tick transcr...
ORGANISM(S): Ixodes scapularis 
2016-01-06 | E-GEOD-68881 | biostudies-arrayexpress
GenomicsPol III ChIP-seq of liver cancer cell lines
This dataset has been designed to test whether codons in mRNAs and anticodons in tRNAs vary in order to maximize translation in specific cellular conditions in mammals. Prokaryotes and simple unicellular eukaryotes optimize their translational rates by adjusting the codons in the protein-coding tran...
ORGANISM(S): human 
2016-04-18 | E-MTAB-4046 | biostudies-arrayexpress
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