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ProteomicsMilk bottom-up proteomics: method optimisation.
Milk is a complex fluid whose proteome displays a diverse set of proteins of high abundance such as caseins and medium to low abundance whey proteins such as ß-lactoglobulin, lactoferrin, immunoglobulins, glycoproteins, peptide hormones and enzymes. A sample preparation method that enables high repr...
ORGANISM(S): Bos taurus (Bovine) 
2016-01-26 | PXD002529 | Pride
Replicates. Jersey and holstein cow milk Trypsin digestion Proteome Nlc-esi-ms 
ProteomicsA multiple protease strategy to optimise shotgun proteomics of medicinal cannabis mature buds.
Earlier this year we published a method article aimed at optimising protein extraction from mature buds of medicinal cannabis for trypsin-based shotgun proteomics (Vincent, D., et al. Molecules 2019, 24, 659). We then developed a top-down proteomics (TDP) method (Vincent, D., et al. Proteomes 2019, ...
ORGANISM(S): Cannabis Sativa (marijuana) 
2019-08-19 | MSV000084216 | MassIVE
MetabolomicsAzithromycin promotes relapse by disrupting immune and metabolic networks after allogeneic stem cell transplantation
Administration of azithromycin after allogeneic hematopoietic stem cell transplantation for hematological malignancies has been associated with relapse in a randomized phase 3 controlled clinical trial. Studying 240 samples from patients randomized in this trial is a unique opportunity to better und...
2022-08-22 | MTBLS406 | MetaboLights
ProteomicsA community resource to mass explore the wheat grain proteome and its application to the late-maturity alpha-amylase problem.
Late maturity alpha amylase is a wheat genetic defect causing the synthesis of high isoelectric point alpha amylase in the aleurone as a result of a temperature shock during mid grain development or prolonged cold throughout grain development leading to an unacceptable low falling numbers at harvest...
ORGANISM(S): Triticum Aestivum (ncbitaxon:4565) 
2022-10-23 | MSV000090572 | MassIVE
ProteomicsInvestigation of Age Gelation in UHT Milk.
Milk samples with twelve combinations of k- and b-casein (CN) and b-lactoglobulin (b-Lg) variants were obtained to investigate the effect of protein variant on the mechanism/s of age gelation in ultra-high temperature (UHT) skim milk. Only milk groups with k-CN/b-CN/b-Lg combinations AB/A1A2/AB and ...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) 
2017-10-17 | MSV000081618 | MassIVE
ProteomicsOptimisation of milk protein top-down sequencing using in-source collision-induced dissociation in the maXis quadrupole time-of-flight mass spectrometer.
Top-down sequencing in proteomics has come of age owing to continuous progress brought to LC-MS. The quality and thoroughness of the results depend on the platform used. The latest generation of mass spectrometers displays unprecedented resolving power, very fast scanning rates, and several fragment...
ORGANISM(S): Bos Taurus (cattle) 
2018-02-15 | MSV000082070 | MassIVE
ProteomicsTop-down proteomics of medicinal cannabis.
The revised legislation on medicinal cannabis has triggered a surge of research study in this space. Yet cannabis proteomics is lagging. In a previous study, we have optimised the protein extraction of mature buds for bottom-up proteomics. In this follow-up study, we develop a top-down proteomics st...
ORGANISM(S): Cannabis Sativa (marijuana) 
2019-06-12 | MSV000083970 | MassIVE
ProteomicsQuantitation and identification of intact major milk proteins for high-throughput LC-ESI- Q-TOF MS analyses
Cow's milk is an important source of proteins in human nutrition. On average, cow's milk contains 3.5% protein. The most abundant proteins in bovine milk are caseins and some of the whey proteins, namely beta-lactoglobulin, alpha-lactalbumin, and serum albumin. A number of allelic variants and post-...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) 
2016-08-11 | MSV000080036 | MassIVE
ProteomicsMining the wheat grain proteome.
Bread wheat is the most widely cultivated crop worldwide, used in the production of food products and a feed source for animals. Selection tools that can be applied early in the breeding cycle are needed to accelerate genetic gain for increased wheat production while maintaining or improving grain q...
ORGANISM(S): Triticum Aestivum (bread Wheat) 
2021-10-21 | MSV000088253 | MassIVE
GenomicsMELARISK_SNP_MITF_geno
Genotypes at MITF E318K variant
EGAD00000000122 | EGA
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