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ProteomicsViperin; regulating chondrogenic differentiation via CXCL10 protein secretion
Mutations in the RMRP gene are the origin of cartilage-hair hypoplasia. Cartilage-hair hypoplasia is associated with severe dwarfism caused by impaired skeletal development. However, it is not clear why mutations in the RMRP gene lead to skeletal dysplasia. Viperin is a known substrate of RMRP. Sinc...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-15 | PXD006999 | Pride
Mouse Viperin Chondrogenic differentiation 
ProteomicsViperin inhibits cholesterol biosynthesis and interacts with enzymes in the cholesterol biosynthetic pathway
Many enveloped viruses bud from cholesterol-rich lipid rafts on the cell membrane. Depleting cellular cholesterol impedes this process and results in viral particles with reduced viability. Viperin (virus inhibitory protein endoplasmic reticulum-associated, interferon-induced) is an ER membrane-as...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD023999 | Pride
Viperin  cholesterol regulation  interactome analysis  radical sam enzyme  squalene monooxygenase  lanosterol synthase 
GenomicsViperin restricts viral replication by serving as a translational regulator
Viperin restricts viral replication by serving as a translational regulator
PRJNA595575 | ENA
TranscriptomicsViperin restricts viral replication by serving as a translational regulator
Innate immune responses induce hundreds of interferon-stimulated genes (ISGs), many of which play an important role in antiviral immunity. Viperin, a member of the radical SAM superfamily of enzymes, is the product of one such ISG and it restricts the replication of a broad spectrum of DNA and RNA v...
ORGANISM(S): Homo sapiens 
2022-05-22 | GSE142015 | GEO
GenomicsRT-qPCR analysis in zebrafish Viperin KO fish under VHSV infections
RT-qPCR analysis in zebrafish Viperin KO fish under VHSV infections
PRJNA1051642 | ENA
GenomicsHIV Induces RSAD2/Viperin To Promote Sustained Infection of Monocyte-Derived Macrophages
HIV Induces RSAD2/Viperin To Promote Sustained Infection of Monocyte-Derived Macrophages
PRJNA1063756 | ENA
UnknownViperin Reveals Its True Function.
Not available
S-EPMC8191541 | biostudies-literature
UnknownStructural Insight into the Substrate Scope of Viperin and Viperin-like Enzymes from Three Domains of Life.
Not available
S-EPMC8672371 | biostudies-literature
GenomicsPIK3CA mutation in endometrial epithelia promotes Viperin-dependent inflammatory response to insulin 3
PIK3CA mutation in endometrial epithelia promotes Viperin-dependent inflammatory response to insulin 3
PRJNA889546 | ENA
UnknownThe antiviral enzyme viperin inhibits cholesterol biosynthesis.
Not available
S-EPMC8254119 | biostudies-literature
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