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MetabolomicsCeramide Promotes Lytic Reactivation of Epstein-Barr Virus in Gastric Carcinoma
Epstein-Barr virus (EBV) has a lifelong latency period after initial infection. Rarely, however, when the EBV immediate early gene BZLF1 is expressed by a specific stimulus, the virus switches to the lytic cycle to produce progeny viruses. We found that EBV infection reduced levels of various cerami...
2023-12-20 | MTBLS7649 | MetaboLights
ProteomicsProtemics of human cell during HHV-6A reactivation
HHV-6A is a human herpesvirus that integrates into human sub telomeric regions to acquire latency. This latent virus frequently reactivates causing numerous diseases. The project was aimed to understand changes in host cell prteomics upon virus reactivation, which might helpin understanding the path...
ORGANISM(S): Homo sapiens (Human) 
2020-04-07 | PXD016211 | Pride
Hhv-6a Viral reactivation 
TranscriptomicsThe viral and cellular microRNA targetome in lymphoblastoid cell lines
Epstein-Barr virus (EBV) is a human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-41437 | biostudies-arrayexpress
ProteomicsMycobacterium tuberculosis normoxia hypoxia reactivation with ActivX-desthiobiotin FP probe
Lysates of Mycobacterium tuberculosis (H37Rv auxotroph mc(2)6020) grown under various conditions (normoxia, hypoxia, reactivation from hypoxia) probed the serine hydrolase probe with ActivX-desthiobiotin FP.
ORGANISM(S): Mycobacterium Tuberculosis (ncbitaxon:1773) 
2016-10-10 | MSV000080238 | MassIVE
TranscriptomicsHelminth Infection Reactivates Latent γ-herpesvirus Via Cytokine Competition at a Viral Promoter
Mammals are co-infected by multiple pathogens that interact through unknown mechanisms. We found that helminth infection, characterized by the induction of the cytokine interleukin-4 (IL-4) and the activation of the transcription factor Stat6, reactivated murine gammaherpesvirus infection in vivo. I...
ORGANISM(S): Mus musculus 
2014-06-26 | E-GEOD-58116 | biostudies-arrayexpress
TranscriptomicsTiled Microarray Identification of Novel Viral Transcript Structures and Distinct Transcriptional Profiles During Two Modes of Productive Murine Gammaherpesvirus 68 Infection.
We applied a custom tiled microarray to examine murine gammaherpesvirus 68 (MHV68) polyadenylated transcript expression in a timecourse of de novo infection of fibroblast cells and following phorbol ester-mediated reactivation from a latently-infected B cell line. During de novo infection, all ORFs ...
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-35866 | biostudies-arrayexpress
TranscriptomicsGene transcription in carbamazepine- and minocycline-induced DRESS
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe, drug-induced reaction that involves both the skin and viscera. To understand the immunological components of DRESS, we prospectively assessed 40 DRESS patients. The patients were evaluated for phenotype, cytokine secretion, r...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-23015 | biostudies-arrayexpress
ProteomicsLactylation of NAT10 promotes N4‐acetylcytidine modification on tRNASer-CGA-1-1 to boost oncogenic DNA virus KSHV reactivation
N4-acetylcytidine (ac4C), a conserved but recently rediscovered RNA modification on tRNAs, rRNAs and mRNAs, is catalyzed by N-acetyltransferase 10 (NAT10). Lysine acylation is a ubiquitous protein modification that controls protein functions. Our latest study demonstrates a NAT10-dependent ac4C modi...
ORGANISM(S): Homo Sapiens 
PXD049447 |
ProteomicsTemporal Analysis of Cell Protein Ubiquitination during Epstein-Barr Virus Reactivation by BCR Cross-linking
Epstein-Barr virus (EBV) reactivation in latently infected B cells is essential for persistent infection and B cell receptor (BCR) activation is a physiologically relevant stimulus for EBV reactivation. Post-translational modifications, such as phosphorylation and ubiquitination, are known to be reg...
ORGANISM(S): Homo sapiens (Human) 
2017-02-02 | PXD004562 | Pride
Epstein barr virus  ubiquitination  reactivation  silac  proteomics  apoptosis Bcr 
TranscriptomicsTiled Array Experiment of Murine Gammaherpesvirus 68 Transcripts Upon TPA-Stimulated Reactivation From Latency
Murine A20 B cells harboring latent MHV68 were treated with TPA and RNA expression was examined over a 24 hour timecourse experiment. Study includes 4 samples- an untreated sample and reactivation samples isolated at 6, 12, and 24 hours after treatment of a latent MHV68+ B cell line with TPA.
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-35865 | biostudies-arrayexpress
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