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MetabolomicsControlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti-viral immunity
Virus-infected cells often exhibit dramatic cellular changes accompanied by altered mitochondrial function. The contribution of factors shaping the inner mitochondrial membrane (IMM) and cristae architecture on viral replication is insufficiently understood. Single cell transcriptomics applying vesi...
2025-06-24 | MTBLS12437 | MetaboLights
MetabolomicsBrain corticogenesis promotes SARS-CoV-2 neuro-glial tropism through lipid-dependent viral replication
While extensive research has examined the neuroinvasiveness of SARS-CoV-2, its relationship with brain maturation remains unclear. Using a multi-omics approach, we established cerebral organoids (CBOs) at day 60 (EB60) and day 120 (EB120) to model immature and mature developmental stages. We found t...
2026-06-18 | MTBLS14790 | MetaboLights
MetabolomicsInfection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication
Peroxisomes are primarily metabolic organelles with important functions in lipid metabolism, such as fatty acid oxidation and ether phospholipid synthesis (e.g. plasmalogens). Certain viruses, such as human cytomegalovirus (HCMV), hijack organelle functions to facilitate their replication and spread...
2018-10-22 | MTBLS652 | MetaboLights
MetabolomicsUntargeted metabolomics reveals bovine viral diarrhea virus infection reprogram host nucleotide and amino acid metabolism in MDBK Cells

Bovine viral diarrhea virus (BVDV) is a highly adapted intracellular parasite that depends entirely on the host cell's metabolic resources and energy for the synthesis of viral components. However, the mechanisms by which BVDV remodels host lipid metabolism remain unclear. In this study, we explo...

2025-10-12 | MTBLS13126 | MetaboLights
MetabolomicsPorcine epidemic diarrhea virus manipulates IMPDH-dependent nucleotide biosynthesis to facilitate replication

Porcine epidemic diarrhea virus (PEDV) causes acute intestinal disease in pigs and remains a major threat to the global swine industry due to its high morbidity and mortality in neonatal piglets. To investigate host metabolic alterations upon PEDV infection, we performed untargeted metabolomic pr...

2025-10-17 | MTBLS13153 | MetaboLights
MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
TranscriptomicsThe Relationship between Virus Replication and Host Gene Expression in Lymphatic Tissue during HIV-1 Infection
During HIV-1 infection, there is a massive perturbation of host gene expression, but as yet, genome-wide studies have not identified host genes affecting HIV-1 replication in lymphatic tissue, the primary site of virus-host interactions. In this study, we isolated RNA from the inguinal lymph nodes ...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-21589 | biostudies-arrayexpress
TranscriptomicsmicroRNA-mediated GALNT3 upregulation facilitates mucin production and viral replication in influenza A virus-infected respiratory epithelial cells
Viral infections affecting the upper or lower respiratory tract induce mucin production in the epithelial surfaces of the respiratory cells. However, a little is known about how mucins are produced on the surfaces of respiratory epithelial cells and affects viral replication. In the course of the in...
ORGANISM(S): Homo sapiens 
2015-12-08 | E-GEOD-57508 | biostudies-arrayexpress
ProteomicsSwapped genetic code block viral infections and gene transfer
Removing cellular transfer RNAs (tRNAs), making their cognate codons unreadable, creates a genetic firewall that prevents viral replication and horizontal gene transfer. However, numerous viruses and mobile genetic elements encode parts of the translational apparatus, including tRNAs, potentially re...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2022-07-08 | MSV000089854 | MassIVE
MetabolomicsBacillus subtilis inhibits African swine fever virus infection in vivo and in vitro based on its metabolites arctiin and genistein interfering with the function of viral topoisomerase II

African swine fever virus (ASFV) is an infectious disease with a mortality rate of nearly 100% in pigs; however, no safe commercial vaccines or antiviral drugs are currently available, which seriously threatens the global pig industry. Therefore, effective biologicals against ASFV are urgently ne...

2023-11-01 | MTBLS6586 | MetaboLights
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