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ProteomicsSILAC E3 ligase activity-based profiling of interferon-stimulated THP-1 cells
Activity-based probes that covalently label proteins with transthiolating E3 ligase activity were used to determine differential changes in E3 ligase activity upon interferon stimulation of monocytic THP-1 cells.
ORGANISM(S): Homo sapiens (Human) 
2026-05-22 | PXD065503 | Pride
Silac Activity-based probes 
ProteomicsUbiquitin diGly site ampping on ZNFX1 autoubiquitination reactions
This experiment aimed to characterise ubiquitin chain linkage preferences generated and autoubiquitination sistes during ZNFX1 E3 reactions using diGly remnant mass spectrometry. GlyGly-modified lysine residues were identified as a qualitative proxy for ubiquitin linkage types. Spectral counts of ra...
ORGANISM(S): Homo sapiens (Human) 
2026-05-22 | PXD073484 | Pride
Znfx1 ubiquitin chains 
ProteomicsZNFX1 activity-based probe crosslinking mass spectrometry
The aim of this experiment was to identify the catalytic cysteine in the antiviral E3 ligase ZNFX1 using activity-based probe (ABP)–enabled cross-linking mass spectrometry (XL-MS). A biotinylated E2~ubiquitin activity-based probe containing a cysteine-electrophile trap was used to covalently capture...
ORGANISM(S): Homo sapiens (Human) 
2026-05-22 | PXD073419 | Pride
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