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TranscriptomicsGenome-wide analysis of mRNA expression alterations of sorted LysM-KI LSK cells versus control LSK cells
Microarrays were used to examine gene expression changes between bone marrow isolated haematopoeietic cell populations (LSK cells: Lin-Sca1+cKit+) populations of control and mutant (LysM-KI) mice. The LysM-KI mouse is a murine model which expresses an Idh1 (isocitrate dehydrogenase 1) mutation (I...
ORGANISM(S): Mus musculus 
2012-07-21 | E-GEOD-38589 | biostudies-arrayexpress
TranscriptomicsLung cancer
Two prognostically significant subtypes of high-grade lung neuroendocrine tumors independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles. BACKGROUND: Classification of high-grade neuroendocrine tumors (HGNT) of the lung currently recognises large-ce...
ORGANISM(S): Homo sapiens 
2004-02-10 | E-GEOD-1037 | biostudies-arrayexpress
TranscriptomicsGene array analysis of embryonic vs adult hypothalamic NPY expressing cell lines
Microarrays were used to examine gene expression changes between two hypothalamic cell lines derived from adult and embryonic tissues. Both cell lines endogenously express the protein Npy (neuropeptide y) which is involved in feeding and reproductive processes. Results identify novel gene candidates...
ORGANISM(S): Mus musculus 
2012-05-31 | E-GEOD-30467 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of mRNA expression alterations in Stage III-IV high-grade serous ovarian cancer patients exhibiting clinically defined differences in ascites volume (high volume ascites versus low volume ascites)
Microarrays were used to examine gene expression changes in the surgical resections of high-grade serous ovarian cancer patients exhibiting clinically distinct levels of ascites volume. The present studies primary aim was to determine if there is a molecular gene expression difference between the ...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-51831 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of mRNA expression alterations of mucosa associated lymphoid tissue lymphoma translocation gene 1 (Malt1) -/- or Wild Type (WT) Naïve T cells induced to differentiate into (T helper) Th1 or Th17 cells
Microarrays were used to examine gene expression changes at two time points following the induction of differentiation of Malt1 deficient Naive T cells into Th1 or Th17 cells. The present study aims to find the effect that Malt1 deficiency has on lineage specific T cell differentiation. Malt1 is a...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-40931 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of Yap mutant kidneys
Microarrays were used to examine gene expression changes between control and mutant (YapCM-/-) kidneys to investigate molecular changes responsible for abnormal nephrogenesis seen in Yap mutants. This work identifies a list of potential genes regulated by Yap during nephron development. Total RNA ob...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-39550 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of mRNA expression alterations in human primary hepatocytes compared with cAMP treated and non-treated human embryonic stem cell (hESC) derived hepatic populations
Microarrays were used to examine gene expression differences between primary human hepatocytes and hESC derived hepatoblast cultures treated or non-treated with cAMP. hESC's were differentiated with a hepatic cell lineage specific protocol that included the use of a 3-dimensional cell aggregation cu...
ORGANISM(S): Homo sapiens 
2013-07-04 | E-GEOD-39157 | biostudies-arrayexpress
TranscriptomicsExpression data from non-malignant fallopian tube epithelium
Microarrays were used to examine gene expression changes that may be present in the fallopian tube epithelium of morphologically normal BRCA1 mutation positive and negative subjects. Fallopian tube epithelia has been implicated as an early point of origin for serous carcninoma. By examining the earl...
ORGANISM(S): Homo sapiens 
2011-04-28 | E-GEOD-28044 | biostudies-arrayexpress
TranscriptomicsIdentification of early targets of SOX2 and PI3K signaling in normal, patient-derived tracheal basal cell lines.
Microarrays were used to examine gene expression changes in patient derived tracheal basal cell lines after treatment with Lenti-SOX2. Comparisons were made between baseline, Lenti-SOX2 and Lenti-SOX2 with a PI3K inhibitor (BKM120). Total RNA obtained from celll lnes 36 hours post lentivirus additio...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-59866 | biostudies-arrayexpress
TranscriptomicsGlucocorticoid-induced reversal of IL1b stumulated gene expression in OE-E6/7 cells
Studies indicate that high-grade serous ovarian carcinoma (HGSOC), the most common epithelial ovarian carcinoma histotype, originates from the fallopian tube epithelium (FTE). Risk factors for this cancer include reproductive parameters associated with lifetime ovulatory events. Ovulation is an ac...
ORGANISM(S): Homo sapiens 
2015-01-27 | E-GEOD-54608 | biostudies-arrayexpress
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