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UnknownNew virulence-activated and virulence-repressed genes identified by systematic gene inactivation and generation of transcriptional fusions in Bordetella pertussis.
Not available
S-EPMC94716 | biostudies-literature
UnknownTrxR, a new CovR-repressed response regulator that activates the Mga virulence regulon in group A Streptococcus.
Not available
S-EPMC2546847 | biostudies-literature
MetabolomicsAnalysis of Growth Phases of Enterotoxigenic Escherichia coli Reveals a Distinct Transition Phase before Entry into Early Stationary Phase with Shifts in Tryptophan, Fucose, and Putrescine Metabolism and Degradation of Neurotransmitter Precursors

Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhea in children and adults in endemic areas. Gene regulation of ETEC during growth in vitro and in vivo needs to be further evaluated, and here we describe the full transcriptome and metabolome of ETEC dur...

2022-07-15 | MTBLS3540 | MetaboLights
UnknownRational design of an artificial genetic switch: Co-option of the H-NS-repressed proU operon by the VirB virulence master regulator.
Not available
S-EPMC3194901 | biostudies-literature
TranscriptomicsCodY in Staphylococcus aureus: regulatory link between metabolism and virulence gene expression
CodY is a conserved regulator in gram-positive organisms described to repress metabolic genes mainly involved in nitrogen metabolism but also to control the expression of virulence genes in pathogens. We constructed codY gene-replacement mutants in three unrelated S. aureus strains (Newman, UAMS-1, ...
ORGANISM(S): Staphylococcus aureus subsp. aureus USA300 
2008-11-06 | E-GEOD-12340 | biostudies-arrayexpress
TranscriptomicsAdult bovine serum (10%) alters the expression of Pseudomonas aeruginosa genes
As production of virulence factors by Pseudomonas aeruginosa is influenced by the host environment, we examined the effect of 10% adult bovine serum (ABS) on the global transcription with P. aeruginoas PAO1 at different phases of growth. At early exponential phase (4 h), serum significantly enhance...
ORGANISM(S): Pseudomonas aeruginosa 
2012-07-08 | E-GEOD-30698 | biostudies-arrayexpress
TranscriptomicsRole of DksA in the pathogenesis and physiology of Campylobacter jejuni.
DksA is well-known for its regulatory role in the transcription of ribosomal RNA and genes involved in amino acid synthesis in many bacteria. DksA is also reported to control expression of virulence genes in pathogenic bacteria. Here, we elucidated the roles of the DksA-like protein (CJJ81176_0160, ...
ORGANISM(S): Campylobacter jejuni subsp. jejuni 81-176 
2008-05-05 | E-GEOD-9866 | biostudies-arrayexpress
TranscriptomicsGene regulation by the RcsCB two-component system and the auxiliary protein TviA in S. Typhi
In response to osmolarity, Salmonella enterica serotype Typhi (S. Typhi) regulates genes required for Vi capsular antigen expression oppositely to those required for motility and invasion. Previous studies suggest that osmoregulation of motility, invasion and capsule expression is mediated through t...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhi 
2010-05-18 | E-GEOD-15752 | biostudies-arrayexpress
GenomicsCovS Inactivation Reduces CovR Promoter Binding at Diverse Virulence Factor Encoding Genes in Group A Streptococcus
We performed CovR ChIP-seq analysis in the emm1 strain MGAS2221 and its CovS kinase deficient derivative strain 2221-CovS-E281A. We identified that CovR bound in the promoter regions of nearly all virulence factor encoding genes in the CovR regulon. Additionally, direct CovR binding was observed for...
ORGANISM(S): Streptococcus pyogenes 
2022-01-03 | GSE192795 | GEO
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis grown at reduced oxygen tension to identify regulators of the hypoxic response
Unlike many pathogens that are overtly toxic to their hosts, the primary virulence determinant of Mycobacterium tuberculosis appears to be its ability to persist for years or decades within humans in a clinically latent state. Since early in the 20th century latency has been linked to hypoxic condit...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-12 | E-TABM-312 | biostudies-arrayexpress
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