Gene regulation by the RcsCB two-component system and the auxiliary protein TviA in S. Typhi

ABSTRACT: In response to osmolarity, Salmonella enterica serotype Typhi (S. Typhi) regulates genes required for Vi capsular antigen expression oppositely to those required for motility and invasion. Previous studies suggest that osmoregulation of motility, invasion and capsule expression is mediated through the RcsC/RcsD/RcsB phosphorelay system. Here we performed gene expression profiling and functional studies to determine the role of TviA, an auxiliary protein of the RcsB response regulator, in controlling virulence gene expression in S. Typhi. TviA repressed expression of genes encoding flagella and the invasion associated type III secretion system (T3SS-1) through repression of the flagellar regulators flhDC and fliZ, resulting in reduced invasion and reduced expression of FliC. Both RcsB and T

ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhi

SUBMITTER: Andreas Baumler 

PROVIDER: E-GEOD-15752 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress